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All Truth passes through Three Stages: First,
it is Ridiculed. Second, it is Violently Opposed... Third, it is Accepted as being Self-Evident.
- Arthur Schopenhauer (1778-1860) By Charly Groenendijk           Back to Side-Effects
The Netherlands
2000 - 2009

 
  Long-Term Side Effects Surface With SSRIs  
 

"Who does Not Know the Truth, is simply a Fool...
Yet who Knows the Truth and Calls it a Lie, is a Criminal."
- In "Galileo Galilei" by Berthold Brecht (1898-1956)

Take notice that also non SSRI antidepressants (and even Ritalin) may interact (primary or secondary) with the serotonergic (or serotoninergic) system in the brain. Every medication -especially SSRI antidepressants- boosting serotonin activity in the brain, has potential to induce the very dangerous and potentially fatal hyperserotonergic state of the Serotonin Syndrome.
SSRI Antidepressants general side-effects, neurological damage
Selective Serotonin / Nor-Epinehrine Re-Uptake Inhibitors
Go to Introduction Antidepressants Negative personality, perception & physical changes
Go to Antidepressant Casualties in the Media Aggression, Homicide, Suicide & Self-Harm
Go to Recent Media Articles (SSRI) Antidepressants Pharmaceutical & FDA Fraud in 2004
Insomnia, weight gain, sexual dysfunction emerge as problems affecting compliance
Physicians are seeing long-term side effects with selective serotonin reuptake inhibitors far in excess of what was expected from clinical trial data. Experience has shown that some side effects are more common and problematic than initially expected, said Dr. Norman Sussman, director of the psychopharmacology research and consultation service at Bellevue Hospital Center in New York. Adverse effects that persist as long as the patient takes the medication are sexual dysfunction and sleep disturbances. Also particularly troubling are those, like weight gain, that don't even develop until late in treatment. "These are the ones that are not in the insert, which is based on short-term studies," Dr. Sussman said. Significant insomnia affects 15%-20% of patients taking SSRIs, twice the rate with placebo. Polysomnography has consistently found that these drugs cause activation during the night resulting in vivid dreams and nightmares. With ongoing treatment, increasing numbers of patients report lethargy and fatigue, he said. Sexual dysfunctions from SSRI side effects such as decreased libido and delayed or absent orgasm are the best known. Perhaps the most unexpected SSRI-related problem to emerge has been weight gain, which often begins only after several months of therapy. This side effect has been reported to occur in 18%-50% of patients in some open-label studies. These observations do contrast with what the clinical trials submitted to the Food and Drug Administration by pharmaceutical companies show, Dr. Sussman said. It would be nice if these long-term side effects were studied in clinical trials comparing different antidepressants.
Clinical Psychiatry News 26(5):1, 1998. 1998 International Medical News Group.

Tardive Dyskinesia/Dystonia, Parkinsonism & Akathisia
SSRI antidepressants induced side-effects (Iatrogenic Extrapyramidal Symptoms) are
recognized to be similar to Neuroleptic (anti-psychotic) induced side-effects. These side-effects are known as Tardive Dyskinesia/Dystonia (severe body movement disorder, mostly permanent), Parkinsonism (a sign of future Parkinson's disease) and Akathisia (a Neurological driven severe mania/agitation that can lead to suicidality, suicide attempts, self-harm & suicide). It is well documented in the medical literature that these neuroleptic induced side-effects refer to damage at dopaminergic neurons in the "motor system" of the
"Basal Ganglia", a structure deep in the "Limbic System" of the brain. 1, 2, 3, 4, http://www.emedicine.com/EMERG/topic338.htm (scroll down)

Serotonin Syndrome
The Serotonin Syndrome is a potentially lethal condition caused by excessive serotonergic activity. It is a very dangerous and a potentially fatal side effect of the serotonergic enhancing drugs such as SSRI antidepressants and is diagnosed by the presence of at least 3 of 10 symptoms: mental status changes (confusion, hypomania), agitation, myoclonus, hyperreflexia, diaphoresis, shivering, tremor, diarrhea, incoordination, and fever. This "hyperserotonergic" toxic condition requires heightened clinical awareness in order to prevent, recognize, and treat the condition promptly. Promptness is vital because, as we just mentioned, the serotonin syndrome can be fatal and death from this side effect can come very rapidly. The Serotonin syndrome is brought on by excessive levels of serotonin and is difficult to distinguish from the "Neuroleptic Malignant Syndrome" because the symptoms are so similar. The "Neuroleptic Malignant Syndrome" is a serious condition brought on by the use of neuroleptic drugs (anti-psychotics).
Source: Prozac: Panacea or Pandora? by Dr Ann Blake Tracy http://members.aol.com/atracyphd/syndrome.htm
Source: Journal of Clinical Psychiatry

Antidepressant induced neurological and/or physical toxicity (body and/or brain damage) either as a result of prolonged inhibition of P450-2D6 liver-enzymes, or as a result of impairing serotonin metabolism, can take on many forms as described below. A few examples are:   Hyperserotonemia, such as the lifethreatening condition the Serotonin Syndrome, Epileptiform Discharges, Epileptic Seizures and/or Epilepsy, Hypoglycaemia/Hyperglycemia (Low/Elevated Blood Sugar Imbalance), Stroke/Hemorrhagic Syndromes, Frontal Lobe Syndrome, Tardive Dyskinesia/Dystonia, Parkinsonism, Akathisia, Mania, etc...

MEDICAL REPORTS OF SSRI ANTIDEPRESSANT INDUCED (IATROGENIC) SEVERE SYMPTOMS:

SSRI's: NEWBORN BABIES (NEONATAL) NEUROLOGICAL DAMAGE & WITHDRAWAL SIDE EFFECTS
2004 
09/00
 Case/Study Neonatal toxicity: Fluoxetine concentrations in cord & maternal serum
2004 
08/09
 WARNING Health Canada: Potential Neurological Adverse Effects of SSRI's on Newborns
2004 
08/00
 Case/Study Using an SSRI during pregnancy has Damaging Teratogenic Effects on the Fetus
2004 
06/00
 Case/Review Baby SSRI (withdrawal) side-effects: agitation, breathing & suction problems
2004 
02/00
 Case/Study SSRI's during pregnancy: Foetal Brain Damage (Neurobehavioral Disruptions)
2003 
11/00
 Case/Review Neonatal (baby) Large Intraventricular Haemorrhage with maternal use of Paxil
2003 
08/00
 Case/Review Baby SSRI (withdrawal) effects: hypoglycaemia, bradycardia, tachycardia, jaundice
2003 
07/00
 Case/Review Increased risk for neonatal problems after exposure to SSRI's in late pregnancy
2003 
07/14
 Case/Review SSRI's During Pregnancy May Cause Neurologic Symptoms in Newborns
2003 
07/12
 Case/Review Withdrawal symptoms in New Born Baby after exposure to Effexor during pregnancy
2003 
04/16
 Case/Review Neonatal (baby) Convulsions & Subarachnoid Hemorrhage after exposure to Paxil
2001 
09/00
 Case/Review Neonatal Paxil withdrawal syndrome or actually serotonin syndrome?
2001 
03/00
 Case/Review New Born BABY SSRI withdrawal syndrome lasting up to one month after birth
2001 
03/00
 Case/Review New Born BABY Withdrawal Syndrome after exposure to SSRI's Celexa, Paxil, Prozac
2000 
10/11
 Case/Review Prozac Toxicity in preterm infant: marked motor automatism & skin manifestations
1999 
11/00
 Case/Study Breastfeeding while taking Prozac associated with reduced growth infants
1997 
11/00
 Case/Review SSRI's, Breast Milk and Withdrawal Symptoms in Newborn Babies

SSRI Antidepressants: GENERAL PHYSICAL & MENTAL SIDE-EFFECTS
2004 
09/14
 FDA US Antidepressant "BLACK BOX WARNING" On Suicidality Risk Recommended
2004 
06/03
 Health Canada Stronger warnings for SSRI's & other anti-depressants
2004 
03/00
 Case/Review Severe adverse drug reactions of (SSRI) antidepressants
2004 
02/00
 Case/Review Serotonin Syndrome and the use of SSRI's
2004 
01/26
 Case/Review Antidepressant Drugs and Suicidal/Aggressive Behaviors
2003 
06/15
 Case/Review Hyponatraemia with SSRI's
2003 
05/00
 Case/Review Antidepressant withdrawal-induced Mania in patients with mood disorders
2003 
04/04
 Case/Review Clinical Study Dr David Healy: Lines of evidence on risks of suicide with SSRI's
2003 
03/31
 Case/Review SSRI-induced Epileptic Seizures
2002 
00/00
 Case/Review Effects of antidepressant drugs on seizure threshold
2002 
05/08
 Case/Review Amotivational Syndrome (Frontal Lobe Syndrome) Link with SSRI Use in Youth
2002 
03/15
 Case/Review Rare Neurologic Syndrome (Call Fleming Syndrome) Linked to AntiDepressants
2002 
03/07
 Case/Review Antidepressants associated with increased risk of falling in elderly persons
2002 
03/05
 Case/Review Male Breast Neoplasia (cancer) in association with SSRI therapy: report of 3 cases
2002 
02/00
 Case/Review Hepatotoxicity (liver damage) associated with the new antidepressants
2002 
01/00
 Case/Review Cerebral Vasoconstriction and Stroke after use of Serotonergic Drugs
2001 
06/00
 Case/Review Amotivational (Frontal Lobe) Syndrome with SSRI's in children & adolescents
2001 
01/20
 Case/Review Selective serotonin uptake inhibitors and Pancreatitis
2000 
12/00
 Case/Review Serotonergic antidepressants and Urinary Incontinence
2000 
10/24
 Case/Review Post-SSRI LSD Flashbacks in Teenagers Related Link
2000 
05/00
 Case/Review Antidepressants can result in Toxicity and Death through serotonergic excess
2000 
05/00
 Case/Review SSRI Discontinuation Syndrome/Withdrawal: proposed diagnostic criteria
2000 
05/17
 Case/Review Antidepressant-Associated Mania & Psychosis Resulting in Psychiatric Admissions
2000 
03/00
 Case/Review Bleeding and selective serotonin reuptake inhibitors in childhood and adolescence
2000 
02/00
 Case/Review Hemorrhagic syndromes related to SSRI's. 7 case reports & review of literature
2000 
02/00
 Case/Review SSRI antidepressant drugs appear to Enhance Cocaine-induced Toxicity
1999 
00/00
 Case/Review Case Report: SSRI-induced Parkinsonism (future Parkinson's)
1999 
00/00
 Case/Review Antidepressants and seizure susceptibility: from in vitro data to clinical practice
1999 
07/00
 Case/Review Selective serotonin reuptake inhibitor Discontinuation/Withdrawal Symptoms
1999 
03/00
 Case/Review Antidepressant Exacerbation of Spasticity
1999 
03/00
 Case/Review Adverse Reactions of SSRI's: reports from a spontaneous reporting system
1998 
00/00
 Case/Review Antidepressant drugs: disturbing and potentially dangerous adverse effects
1998 
00/00
 Case/Review SSRI-induced Extrapyramidal side-effects & Akathisia: implications for treatment
1998 
11/09
 Case/Review Antidepressant Discontinuation-Related Mania also in Bipolar Depression
1996 
10/00
 Case/Review Movement Disorders associated with the serotonin selective reuptake inhibitors
1996 
10/00
 Case/Review SSRI Side-Effects: Akathisia, Dystonia, Parkinsonism & Tardive Dyskinesia
1996 
10/00
 Case/Review Serotonin reuptake inhibitor withdrawal
1996 
09/01
 Case/Review Hyponatremia & SIADH associated with SSRI's: a review of spontaneous reports
1991 
12/00
 Case/Review Serotonin reuptake inhibitors, Paranoia & the Ventral Basal Ganglia

Medical reports: BODY MOVEMENT DISORDERS (DYSTONIA) & PARKINSONISM (future Parkinson's disease)
2003 
07/22
 Case/Review Bupropion: Tremors, Agitation, Confusion, Insomnia & Rash
2002 
00/00
 Case/Review Fluoxetine-induced Torticollis, Bradykinesia & Cogwheel Rigidity in an adolescent
2002 
12/00
 Case/Review Acute dystonic reaction to paroxetine treatment in elderly patient
2002 
05/00
 Case/Review Case Report: Dystonia Induced by Mirtazapine (Remeron)
2002 
05/08
 Case/Review Fluoxetine-induced Exacerbation of Chorea in Huntington's Disease
2002 
02/00
 Case/Review Bupropion-induced Acute Dystonia
2001 
08/00
 Case/Review Myoclonus secondary to the concurrent use of trazodone and fluoxetine
2001 
07/08
 Case/Review Myoclonus during prolonged treatment with sertraline in an adolescent patient
2001 
02/00
 Case/Review Visual hallucination and tremor induced by sertraline and oxycodone
2001 
04/00
 Case/Review Parkinsonism and Parkinson's disease with long-term sertraline
2000 
04/00
 Case/Review Worsening of Parkinson's Disease
1999 
00/00
 Case/Review Case Report: SSRI-induced Parkinsonism (future Parkinson's)
1998 
09/00
 Case/Review Extrapyramidal Adverse Effects associated with Zoloft/Lustral
1998 
07/00
 Case/Review Involuntary Movement Disorders associated with Sertraline
1998 
06/00
 Case/Review Sertraline induced Parkinsonism. A case report and an in-vivo study
1998 
06/27
 Case/Review Severe Tardive Dyskinesia (permanent movement disorder) with Prozac & risperidone
1997 
08/00
 Case/Review Venlafaxine produces Sleep Disturbances & Abnormal Leg Movements
1996 
10/00
 Case/Review Movement Disorders associated with the serotonin selective reuptake inhibitors
1996 
10/00
 Case/Review SSRI Side-Effects: Akathisia, Dystonia, Parkinsonism & Tardive Dyskinesia
1996 
09/00
 Case/Review Tardive Dyskinesia (permanent body movement disorder) with Prozac/Sarafem
1996 
07/13
 Case/Review Zoloft/Lustral: Extrapyramidal Symptoms such as Rigidity and Tremors...
1996 
05/00
 Case/Review Complex Movement Disorders induced by fluoxetine
1995 
10/00
 Case/Review Parkinsonism associated with fluoxetine and cimetidine: a case report
1995 
01/00
 Case/Review Worsening Tremor & Problems with Word-Finding following fluoxetine treatment
1994 
06/00
 Case/Review Fluoxetine induced Dyskinesia
1994 
05/00
 Case/Review Reversible Intermittent Rhythmic Myoclonus with fluoxetine in pres. Pick's disease
1993 
01/00
 Case/Review Increase of Parkinson Disability after fluoxetine medication
1979 
00/00
 Case/Review Dystonic Reaction, Parkinsonian Rigidity & Increased Serum Prolactin levels

Medical reports, side-effects: AKATHISIA, MANIA, RESTLESSNESS & RESTLESS LEGS SYNDROME
2003 
12/00
 Case/Review Fluoxetine (Prozac) dose-increment related Akathisia in depression
2003 
10/00
 Case/Study Induction of mania in depression by Paxil/Seroxat (paroxetine)
2003 
07/00
 Case/Review Case report Zoloft (Lustral, sertraline)-induced Hypomania: a genuine side-effect
2003 
06/00
 Case/Review Mania associated with Effexor (Efexor, venlafaxine) discontinuation
2003 
04/00
 Case/Review Eroto-Mania induced by Effexor (venlafaxine): a case study
2002 
12/00
 Case/Review Restless Legs Syndrome induced by Remeron (mirtazapine)
2002 
12/00
 Case/Review Worsening of autosomal dominant Restless Legs Syndrome after use Mirtazapine
2002 
11/00
 Case/Review Dysphoric Mania with high-dose Mirtazapine: a case for Norepinephrine Syndrome?
2002 
11/00
 Case/Review Zoloft/Lustral-Induced Akathisia and Dystonia Misinterpreted as a Panic Attack
2002 
07/08
 Case/Review High-dose fluoxetine-induced Mania. Review and case report
2002 
06/22
 Case/Review Akathisia due to the higher dose of fluoxetine -scroll to case 3
2002 
03/04
 Case/Review Remeron (Remergil, mirtazapine)-induced acute Akathisia
2001 
06/00
 Case/Review Mania & Paranoid Ideation following Tramadol-Fluoxetine Combination
2000 
01/12
 Case/Review Antidepressant-Induced Mania in Bipolar Patients: Identification of Risk Factors
1999 
03/02
 Case/Review SSRI's induced Mania in obsessive compulsive disorder
1998 
08/00
 Case/Study Manic behaviors with Prozac (fluoxetine) in three 12- to 18-year-olds with OCD
1998 
08/00
 AnimalStudy Reduced activity of rat dopaminergic neurons in the VTA may explain "Akathisia"
1998 
06/00
 Case/Review Hypomania associated with mirtazapine augmentation of sertraline
1997 
02/00
 No Abstract Mania associated with serotonin selective reuptake inhibitors
1996 
12/00
 Case/Review Restless legs syndrome worsened by Paxil/Seroxat (paroxetine)
1996 
10/00
 Case/Review SSRI Side-Effects: Akathisia, Dystonia, Parkinsonism & Tardive Dyskinesia
1996 
05/00
 No Abstract SSRI-induced Akathisia
1996 
03/04
 Case/Review Akathisia: a review and case report following paroxetine treatment
1995 
09/00
 No abstract Paxil (Seroxat, paroxetine)-induced psychotic mania
1995 
08/00
 Case/Review Antidepressant-induced Mania and Cycle Acceleration: a controversy revisited
1994 
11/00
 Case/Review Antidepressant-associated Mania: a controlled comparison with spontaneous mania
1994 
09/10
 Case/Review Revisiting Fluoxetine: Akathisia & Suicidal Preoccupations
1992 
11/00
 Case/Review Akathisia, Suicidality and Prozac/Sarafem (FLUOXETINE)
1992 
07/00
 Case/Review Prozac (fluoxetine) treatment: Restlessness, Hyperactivity, Agitation, Insomnia
1992 
03/00
 Case/Review Mania associated with Prozac/Sarafem (fluoxetine) treatment in adolescents
1991 
12/00
 Case/Review Prozac-induced Serious Suicide Attempts by 3 patients: the Role of Akathisia
1989 
09/00
 Case/Review Typical Prozac/Sarafem-induced Akathisia: clinical and theoretical implications
1984 
02/00
 Case/Review A case of mania associated with Prozac/Sarafem (fluoxetine)

Medical reports, side-effects: SEROTONIN SYNDROME, NEUROLEPTIC MALIGNANT SYNDROME
2004 
02/00
 Case/Review Serotonin Syndrome and the use of SSRI's
2003 
05/27
 Case/Review Serotonin Syndrome: a brief review -case 1 fluoxetine
2003 
05/06
 Case/Review Serotonin Syndrome induced by Remeron/Remergil (Mirtazapine)
2003 
05/00
 Case/Review Fatal Serotonin Syndrome after combined treatment with linezolid
2003 
02/00
 Case/Review Serotonin Syndrome Induced by Low-Dose Effexor (venlafaxine)
2002 
09/00
 Case/Review Neuroleptic Withdrawal vs Serotonergic Syndrome in 8-year-old child on fluoxetine
2002 
04/00
 Case/Review Case of a patient with Fluoxetine & Selegiline induced Fatal Serotonin Syndrome
2002 
04/00
 Case/Review Severe Serotonin Syndrome induced by Mirtazapine monotherapy
2002 
03/04
 Case/Review Serotonin Toxicity with therapeutic doses of dexamphetamine and venlafaxine
2002 
02/00
 Case/Review Serotonin Syndrome present. as Hypotonic Coma & Apnea (fluoxetine & citalopram)
2001 
10/00
 Case/Review Serotonin Syndrome induced by Fluvoxamine and Mirtazapine
2001 
09/00
 Case/Review Neonatal paroxetine withdrawal syndrome or actually serotonin syndrome?
2001 
03/00
 Case/Review A Fatal Case of Serotonin Syndrome after moclobemide-citalopram intoxication
2000 
04/00
 Case/Review Venlafaxine-induced Serotonin Syndrome with relapse following amitriptyline
2000 
03/00
 Case/Review Serotonin Syndrome during fluoxetine-poisoning in a patient taking moclobemide
2000 
02/00
 Case/Review Case Report: Serotonin Syndrome with Serzone and Prozac
2000 
01/22
 Case/Review Neuroleptic Malignant Syndrome after venlafaxine
1999 
09/00
 Case/Review Serotonin syndrome associated to the use of paroxetine. Case report
1999 
07/00
 Case/Review Serotonin syndrome secondary to the use of sertraline and metoclopramide
1999 
07/08
 Case/Review Serotonin syndrome in a child associated with erythromycin and sertraline
1998 
00/00
 Case/Review Antidepressant drugs: disturbing and potentially dangerous adverse effects
1998 
09/00
 Case/Review Serotonin Syndrome due to venlafaxine overdose
1998 
07/00
 Case/Review Serotonin Syndrome induced by transitioning from phenelzine to venlafaxine
1998 
07/08
 Case/Review Serotonin Syndrome with Effexor and other SSRI-antidepressants
1998 
04/00
 Case/Review Serotonin Syndrome induced by venlafaxine and fluoxetine
1997 
01/00
 Case/Review  Serotonin Syndrome following a single dose of Effexor (venlafaxine)
1996 
07/12
 Case/Review Isolated venlafaxine-overdose-induced Serotonin Syndrome
1995 
07/08
 Case/Review Serotonin Syndrome in a patient given fluoxetine and lithium
1994 
11/00
 Case/Review Fluoxetine induced Serotonin Syndrome
1994 
11/00
 Case/Review Prozac/Sarafem (fluoxetine)-induced Serotonin Syndrome in 48-year-old man
1994 
11/00
 Case/Review Serotonin Syndrome with Paxil/Seroxat, an OTC cold remedy, and vascular disease
1990 
09/15
 Case/Review Neuroleptic Malignant Syndrome with Prozac/Sarafem (fluoxetine)

Medical reports, side-effects: BLOOD/ORGAN DISEASES, STROKE, HEMORRHAGE, TIA, TUMOURS & BLEEDINGS
2004 
04/00
 Case/Review Transient ischemic attack (TIA) reported with Paxil/Seroxat (paroxetine) use
2003 
00/00
 Case/Review SSRI-Associated Bleeding: The Risk of Treating Hepatitis C-Infected Patients
2003 
11/00
 Case/Review Neonatal (baby) Large Intraventricular Haemorrhage with maternal use of Paxil
2003 
05/06
 Case/Review Severe Thrombocytopenia in a 66-year-old patient after Mirtazapine administration
2003 
04/00
 Case/Review Effexor-induced Pneumonitis (Lung Reaction) & Heart Failure simultaneously
2003 
04/16
 Case/Review Neonatal (baby) Convulsions & Subarachnoid Hemorrhage after exposure to Paxil
2003 
02/00
 Case/Review Respiratory Distress Syndrome & Renal Failure with overdose
2003 
01/00
 Case/Review Bupropion: Thrombotic Thrombocytopenic Purpura-hemolytic Uremic Syndrome
2002 
12/00
 Case/Review Ecchymosis with Prozac (hemorrhage under the skin, sign of liver dysfunction)
2002 
09/00
 Case/Review Massive peroperative haemorrhage, result of Paxil-induced thrombocytopathy
2002 
09/00
 Case/Review Mirtazapine-induced Severe Neutropenia
2002 
05/00
 Case/Review Effexor/Efexor (venlafaxine)-associated Vaginal Bleeding
2002 
05/08
 Case/Review Amotivational Syndrome (Frontal Lobe Syndrome) Link with SSRI Use in Youth
2002 
03/15
 Case/Review Rare Neurologic Syndrome (Call Fleming Syndrome) Linked to AntiDepressants
2002 
03/05
 Case/Review Male Breast Neoplasia (cancer) in association with SSRI therapy: report of 3 cases
2002 
01/00
 Case/Review Cerebral Vasoconstriction and Stroke after use of Serotonergic Drugs
2001 
06/00
 Case/Review Amotivational (Frontal Lobe) Syndrome with SSRI's in children & adolescents
2001 
01/20
 Case/Review Selective serotonin uptake inhibitors and Pancreatitis
2000 
09/00
 Case/Review Paroxetine and Irritable Bowel Syndrome
2000 
05/15
 Case/Review Paroxetine use associated with a substantial increase in Breast Cancer Risk
2000 
04/00
 Case/Review Hypertensive Urgency (high blood pressure) by Mirtazapine/Clonidine interaction
2000 
03/00
 Case/Review Bleeding and selective serotonin reuptake inhibitors in childhood and adolescence
2000 
02/00
 Case/Review Hemorrhagic syndromes related to SSRI's. 7 case reports & review of literature
2000 
01/00
 Case/Review Effexor: Eosinophilic Pneumonia (Lung/Blood Disease) & Respiratory Failure
1999 
00/00
 Case/Review Acute Ischaemic Event associated with the use of venlafaxine
1999 
11/00
 Case/Review Hyperthyroidism secondary to antidepressive treatment with fluoxetine
1999 
05/00
 Case/Review Ileus as a Possible Result of Bupropion in an Elderly Woman
1998 
11/00
 Case/Review Overdose: Severe Hypothermia, Cardial & Respiratory Function Compromised
1997 
02/15
 Case/Review Hemodynamic abnormalities & vasoconstriction following paroxetine 40mg per day
1991 
03/00
 Case/Review A fluoxetine-induced Frontal Lobe Syndrome in an obsessive compulsive patient

Medical reports, side-effects: HEPATO TOXICITY (Liver damage)
2003 
00/00
 Case/Review Paxil induced Cholestasis (liver disease where flow of bile from the liver is reduced)
2003 
05/00
 Case/Review Zoloft/Lustral-induced Hepatitis: a case report and review of the literature
2003 
05/00
 Case/Review Hepatic Injury & Pancreatitis during treatment with SSRIs & Effexor
2003 
02/00
 Case/Review Acute Liver Failure with concurrent Bupropion and carbimazole therapy
2003 
02/00
 Case/Review Antidepressant induced Cholestasis
2002 
09/00
 Case/Review Mirtazapine-induced Hepatotoxicity
2002 
06/00
 Case/Review Bupropion-induced Change CYP2D6 Extensive Metabolizer to Poor Metabolizer
2002 
02/00
 Case/Review Hepatotoxicity (liver damage) associated with the new antidepressants
2001 
11/00
 Case/Review Acute Cholestatic Hepatitis induced by Bupropion. A case report
2001 
08/00
 Case/Review Severe hepatotoxicity with jaundice associated with paroxetine
2000 
03/07
 Case/Review Venlaxafine-Associated Hepatitis
1999 
07/00
 Case/Review Acute Hepatitis due to fluoxetine therapy
1999 
06/01
 Case/Review Venlaxafine-Associated Hepatitis
1999 
04/00
 Case/Review Effect of CYP2D6*10 genotype on venlafaxine in healthy adult volunteers
1998 
04/00
 Case/Review Symptomatic Liver Injury probably related to sertraline
1997 
03/15
 Case/Review Severe hepatitis attributed to paroxetine (Seroxat)
1996 
11/00
 Case/Review Reversible severe hepatotoxicity of paroxetine in a patient with major depression
1983 
03/00
 AnimalStudy SSRI-induced Lipidosis in Rats (fat infiltration into liver cells; can cause death)
1978 
00/00
 AnimalStudy SSRI-induced Hepatotoxicity in Rats and first-pass metabolism

Medical reports: CARDIOVASCULAR TOXICITY (Heart damage) & NEUROLOGICAL TOXICITY (Brain damage)
2004 
06/21
 AnimalStudy SSRI disrupts the development of neural circuitry during cortical synaptic formation
2004 
04/00
 Case/Review Amygdala volume reductions in pediatric patients with OCD treated with paroxetine
2003 
04/00
 Case/Review Effexor-induced Pneumonitis (Lung Reaction) & Heart Failure simultaneously
2003 
03/00
 No abstract Provoked bradycardia after Paxil/Seroxat (paroxetine) administration
2002 
00/00
 Case/Review Torsades de Pointes appeared to occur with Remeron (mirtazapine)
2002 
08/00
 Case/Review Acute Myocardial Infarction following Wellbutrin/Zyban (bupropion)
2002 
04/15
 Bio Study Neuronal Cell Death induced by Prozac/Sarafem (fluoxetine)
2001 
12/00
 Case/Review Celexa/Cipramil-Induced Bradycardia, Presyncope & Hypotension
2001 
09/00
 Case/Review Celexa/Cipramil-induced Torsades de Pointes, Prolongation of QT Interval
2000 
02/00
 Case/Review SSRI antidepressant drugs appear to Enhance Cocaine-induced Toxicity
2000 
02/29
 Animal Study Prozac & other SSRI's cause Shriveled & Corkscrew Shaped Brain Cells
1999 
08/00
 Case/Review Influence of CYP2D6 liver-enzymes & Cardiovascular Toxicity of Effexor (venlafaxine)
1999 
02/00
 Case/Review Celexa/Cipramil (citalopram)-induced Sinus Bradycardia
1998 
09/01
 Animal Study Brain cell (neuron) function in forebrain altered by prenatal exposure to Prozac
1998 
08/00
 AnimalStudy Reduced activity of rat dopaminergic neurons may explain "Akathisia" with SSRI's
1998 
07/00
 Case/Review Severe bradycardia an increase in QTc time observed with Paxil/Seroxat
1997 
00/00
 Animal Study Prenatal exposure to Prozac produces changes in brain serotonin (5-HT) neurons
1997 
11/00
 Case/Review Seizures, Tachycardia & Rhabdomyolysis following Effexor & Lamotrigine
1997 
09/00
 Case/Review Prozac (fluoxetine)-induced cardiovascular, neurovascular toxicity & seizure
1996 
10/00
 Case/Review Wellbutrin (bupropion) toxicity by CYP2D6 (liver enzymes) inhibition
1992 
10/00
 AnimalStudy Site specific malformations in mouse embryos following exposure to SSRI's
1992 
09/00
 Case/Review Case report of a Syncopal Episode associated with Prozac/Sarafem (fluoxetine)
1990 
09/00
 Case/Review Prozac/Sarafem (fluoxetine)-induced Bradycardia and Syncope in two patients

Medical reports: EPILEPTIFORM ACTIVITY, SEIZURES, REM SLEEP/MEMORY/EEG PROBLEMS, SLEEPWALKING
2003 
12/00
 Case/Review Memory Loss in a patient treated with Prozac/Sarafem (fluoxetine)
2003 
09/00
 Case/Review Wellbutrin/Zyban-induced Somnambulism (sleepwalking) & Amnesia
2003 
04/16
 Case/Review Neonatal Convulsions & Subarachnoid Hemorrhage after exposure to Paxil/Seroxat
2003 
03/31
 Case/Review SSRI-induced Epileptic Seizures
2003 
02/00
 Case/Review Seizure associated with sleep deprivation & Wellbutrin/Zyban (bupropion)
2003 
01/14
 Case/Review Remeron (mirtazapine) induces REM Sleep Behavior Disorder in parkinsonism
2002 
00/00
 Case/Review Effects of antidepressant drugs on seizure threshold
2002 
00/00
 Case/Review Celexa/Cipramil Induced Severe Hyponatraemia with Coma & Seizure
2002 
04/00
 AnimalStudy Proconvulsant Effects of high doses of Effexor (venlafaxine) in rats
2002 
04/00
 Case/Review Wellbutrin/Zyban common cause of Seizures presenting to Emergency Department
2001 
09/10
 Case/Review Bitemporal Epileptiform Discharges induced by Wellbutrin/Zyban (bupropion)
2001 
07/00
 Case/Review Acute Paroxysmal Dystonia induced by Prozac/Sarafem (fluoxetine)
2001 
06/00
 Case/Review Dose-dependent Seizure Activity associated with Prozac/Sarafem (fluoxetine) therapy
2000 
12/00
 Case/Review Seizures associated with therapeutic doses of Effexor (venlafaxine) & trimipramine
2000 
03/02
 Case/Review SIADH with Epileptic Seizures and Coma in Prozac/Sarafem (fluoxetine) therapy
1999 
00/00
 Case/Review Antidepressants and seizure susceptibility: from in vitro data to clinical practice
1997 
00/00
 Case/Review Toxic Delirium & general Tonic-Clonic Seizure with Prozac & low dose Trazodone
1997 
11/00
 Case/Review Seizures, Tachycardia & Rhabdomyolysis following Effexor & Lamotrigine
1997 
09/00
 Case/Review Prozac (fluoxetine)-induced cardiovascular, neurovascular toxicity & seizure
1996 
00/00
 Case/Review Nightmares and hallucinations after 2-month intake of tramadol & Paxil/Seroxat
1995 
06/00
 Case/Review Use of Wellbutrin/Zyban (bupropion) involves a Higher Seizure Risk
1995 
01/00
 Case/Review Worsening Tremor & Word-Finding Problems following Prozac (fluoxetine) treatment
1994 
08/00
 No Abstract Seizures and antidepressants
1994 
06/00
 No Abstract Antidepressant-associated Seizures
1993 
12/00
 Case/Review Seizures associated with Prozac/Sarafem (fluoxetine) therapy
1993 
09/00
 Case/Review Celexa/Cipramil-Induced Significant Decrease of EEG Power of NREM sleep (8-9hz)
1986 
08/00
 Case/Review A case of Wellbutrin/Zyban (bupropion)-induced Seizure
1986 
06/00
 Case/Review Marketing of Wellbutrin (bupropion) in US delayed after Epileptic Seizures in trials

 Antidepressant Neurological Side-Effects: Addiction & Withdrawal
 Antidepressant Neurological Side-Effects: Akathisia & Mania (Suicide & Aggression)
 Antidepressant Neurological Side-Effects: Serotonin Syndrome
 Antidepressant Neurological Side-Effects: Toxicity & Brain Damage
 Antidepressant Neurological Side-Effects: "Anecdotal" Reports -Personal Experiences

 Antidepressants: How To Wean/Taper Off
 Antidepressants: How to Survive a Negative Reaction
 Antidepressants: Conquering Depression and Anxiety

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