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thrombocytopenic purpura-hemolytic uremic syndrome after bupropion
treatment for smoking cessation.
Mele L, Voso MT,
Fianchi L, Leone G, Pagano L.
Instituto di Ematologia,
Universita Cattolica del Sacro Cuore, Rome, Italy.
Bupropion hydrochloride is an effective drug
for people who want stop smoking, and its use has recently increased in
many countries. The main side effects of this drug are related to its
dopaminergic activity and are dose dependent. To date, no cases of
thrombotic thrombocytopenic purpura-hemolytic uremic syndrome (TTP-HUS)
have been reported in literature. Here we describe a case of a woman who
developed a sporadic form of TTP-HUS during a treatment with bupropion
for smoking cessation, successfully treated with plasma ex-change
therapy. The authors wish to make readers aware of bupropion as a
possible cause of this potentially lethal disease. Copyright 2003
Lippincott Williams & Wilkins
PMID: 12544732 [PubMed - indexed for