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Bleeding and selective serotonin
reuptake inhibitors in childhood and
adolescence.
Lake MB, Birmaher B, Wassick S, Mathos
K, Yelovich AK.
Department of Child Psychiatry, Western
Psychiatric Institute and Clinic, University of Pittsburgh School of
Medicine, Pennsylvania 15213, USA.
The selective serotonin
reuptake inhibitors (SSRIs) are becoming widely used in children and
adolescents, with possible unexpected side effects being observed over
time. SSRIs have been associated with bleeding in adults who have
unremarkable routine hematologic laboratory results except abnormal
bleeding time or platelet counts in few cases. Given the increase of
pediatric SSRI prescriptions, in this article we describe five children,
ages 8 through 15, who developed bruising or epistaxis 1 week to 3
months after starting SSRI treatment. It is possible that the effects
SSRI on platelet functioning are causing the bleeding observed in some
patients and/or that a separate coagulopathy is present and contributing
to bleeding. The subject matter deserves future
investigation.
Publication Types:
PMID: 10755580 [PubMed - indexed for
MEDLINE]
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