By Charly Groenendijk Back to Side-Effects
2000 - 2009
Yet who Knows the Truth and Calls it a Lie, is a Criminal."
- In "Galileo Galilei" by Berthold Brecht (1898-1956)
Take notice that also non SSRI anti-depressants (and even Ritalin) may interact (primary or secondary) with the serotonergic (or serotoninergic) system in the brain.
SSRI/SSNRI-induced Toxicity & Brain Damage by disrupting the balance of Body & Brain Metabolism
Originally, the neurotransmitter serotonin -thought to be secreted by the Pineal Gland- is called a neurohormone, because of it's specific regulatory effect on the activity of the Endocrine Glands in the human body. (1),(2) Affecting serotonin thus means also affecting the Glandular Endocrine System. Next to it, serotonin affects the Cardiovascular System and the Respiratory System, under which, the lungs. Serotonin is also found in blood platelets and stimulates platelet aggregation (blood clotting). Furthermore, serotonin is known to affect contraction of smooth muscles (such as those of the gut) and blood vessel elasticity (vasoconstriction and expansion). More information: Serotonin & the Pineal Gland
A recent study (25 sept, 2004) shows us clearly that serotonin toxicity can even appear rapidly in a few hours after taking a single therapeutic dose of SSRI medication. In Bio-Psychiatry it is a common thought that SSRI's are believed to have their effect by inhibiting the re-uptake of serotonin (downregulation of transporters) and thereby gradually increasing serotonin outside the tissue cell wall (extracellular) in the synaptic gap between brain cells (neurons) in the brain. In this important study, Zoloft (Lustral, sertraline) was given to monkeys for 4 weeks to establish how long it would take before Zoloft would have it's effect on serotonergic neurons and thus elevation of serotonin. In contrast with the commonly accepted SSRI theory, it was observed that serotonin levels raised NOT gradually, but rapidly and dramatically and kept on raising during these 4 weeks, an effect that can NOT be ascribed solely to a "re-uptake inhibition" of serotonin!
Antidepressant induced neurological and/or physical toxicity (body and/or brain damage) either as a result of prolonged inhibition of P450-2D6 liver-enzymes, or as a result of impairing serotonin metabolism, can take on many forms as described below. A few examples are: Hyperserotonemia, such as the lifethreatening condition the Serotonin Syndrome, Epileptiform Discharges, Epileptic Seizures and/or Epilepsy, Hypoglycaemia/Hyperglycemia (Low/Elevated Blood Sugar Imbalance), Stroke/Hemorrhagic Syndromes, Frontal Lobe Syndrome, Tardive Dyskinesia/Dystonia, Parkinsonism, Akathisia, Mania, etc...
Tardive Dyskinesia/Dystonia, Parkinsonism & Akathisia
MEDICAL REPORTS OF SSRI/SSNRI ANTIDEPRESSANT INDUCED (IATROGENIC) SEVERE SYMPTOMS:
Go to: Newborn Baby (Neonatal) Neurological Damage & Withdrawal
Go to: General Physical & Mental Side-Effects
Go to: Body Movement Disorders (Dystonia) & Parkinsonism (future Parkinson's disease)
Go to: Akathisia, Mania, Restlessness & Restless Legs Syndrome
Go to: Serotonin Syndrome, Neuroleptic Malignant Syndrome
Go to: Blood/Organ Diseases, Stroke, Hemorrhage, TIA, Tumours & Bleedings
Go to: Hepato Toxicity (Liver Damage)
Go to: Cardiovascular Toxicity (Heart Damage) & Neurological Toxicity (Brain Damage)
Go to: Epileptiform Activity, Epilepsy, Seizures, REM Sleep/Memory/EEG Problems, Sleepwalking
Go to: Hypoglycemia (low blood sugar), Hyperglycemia (high blood sugar, Diabetes)
Go to: Urinary Incontinence, Dermatologic (Skin) Problems, Ocular (Eyes) Disturbances
Go to: Pain & Numbness, Swellings, Sexual (Organ) Problems, Hormonal Imbalances
Go to: Hyponatremia & Syndrome of Inappropriate Secretion of Antidiuretic Hormone (SIADH)
Go to: (Suicide Overdose)-Toxicity & Death
Go to: Suicide, Suicidality, Suicide Attempts & Self-Harm
Go to: Mental State, Perceptual, Emotional & Psychological Changes
Go to: Mental & Physical Side-Effects of Withdrawal/Discontinuation
Go to: Other Observations & Complications: Case Reports, Reviews & Studies
SSRI & SSNRI Antidepressants: NEWBORN BABY (NEONATAL) NEUROLOGICAL DAMAGE & WITHDRAWAL
Abnormalities in Brain Cells (Neurons)
Abnormalities in the "Motor System", deep in older part of the brain (basal ganglia of the limbic system).
Neurological & Physical Side-Effects of dangerous condition "Hyperserotonemia"