About Entrez
Text Version
Entrez PubMed
Overview
Help | FAQ
Tutorial
New/Noteworthy
E-Utilities
PubMed Services
Journals Database
MeSH Database
Single Citation Matcher
Batch Citation Matcher
Clinical Queries
LinkOut
Cubby
Related Resources
Order Documents
NLM
Gateway
TOXNET
Consumer
Health
Clinical Alerts
ClinicalTrials.gov
PubMed
Central
|
 |
-
Induction of mania in depression
by paroxetine.
Morishita S, Arita
S.
Department of Psychiatry, Kawasaki Medical School,
Kurashiki, Okayama, Japan.
morisita@med.kawasaki-m.ac.jp
INTRODUCTION: An investigation of
the proportion of patients who have experienced mania with
antidepressant treatment and their characteristics would seem to be of
clinical use. AIMS: The purpose of this clinical study was to examine
the predictors of induction of mania in depression patients as a result
of paroxetine treatment. METHOD: A retrospective cohort analysis was
carried out among depression patients treated in the Department of
Psychiatry, Kawasaki Medical School Hospital, Kurashiki, Japan, in 2000
and 2001. Some 79 patients were identified who were receiving paroxetine
to treat depression. A variety of clinical factors including gender, the
type of depression, frequency of episodes, family history, age and daily
dose were examined as possible predictors of induction of mania by
paroxetine. RESULTS: Seven (8.86%) of the 79 paroxetine-treated patients
developed mania. A Cox proportional hazards analysis showed the type of
depression and the history of family psychiatric illness to be
independent predictive factors of the induction of mania by paroxetine
treatment. CONCLUSIONS: The rate of mania induction of paroxetine is not
substantially different from that found for conventional
antidepressants. The type of depression and the history of family
psychiatric illness may be considered as predictors of mania induction
in depression patients taking paroxetine treatment. Copyright 2003 John
Wiley & Sons, Ltd.
PMID: 14533140 [PubMed - indexed for
MEDLINE]
|