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Memory loss in a patient
treated with fluoxetine.
Joss JD, Burton RM, Keller
CA.
Ambulatory Services, Good Samaritan Regional Medical
Center, Corvallis, OR, USA. jjoss@samhealth.org
OBJECTIVE: To
report a case of severe memory loss in an elderly patient after
initiation of fluoxetine.CASE SUMMARY: An 87-year-old white woman was
started on fluoxetine for depression, and the dose was titrated to 20
mg/d. She developed progressive memory loss over the next 6 weeks for
which she ultimately was hospitalized. Other potential causes for her
memory loss were ruled out. After fluoxetine was discontinued, the
patient's memory improved significantly over the next 2 months. An
objective causality assessment indicated a possible relationship between
the memory loss and fluoxetine in this patient.DISCUSSION: Our report
documents a case of severe reversible memory deterioration after
initiating fluoxetine. Fluoxetine has a favorable adverse effect profile
when compared with older classes of antidepressants. Postmarketing
studies and isolated case reports, however, suggest that fluoxetine may
harm memory in some patients. Some selective serotonin-reuptake
inhibitors (SSRIs) appear to cause memory loss more frequently than
others.CONCLUSIONS: Clinicians should be aware of the possible effects
of fluoxetine (and possibly other SSRIs) on memory.
PMID:
14632599 [PubMed - in process]
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