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1: J Clin Psychiatry. 1991 Mar;52(3):131-3. Related Articles, Links

Comment in:
A fluoxetine-induced frontal lobe syndrome in an obsessive compulsive patient.

Hoehn-Saric R, Harris GJ, Pearlson GD, Cox CS, Machlin SR, Camargo EE.

Johns Hopkins Medical Institutions Department of Psychiatry and Behavioral Sciences, Baltimore, MD 21205.

The authors report the occurrence of apathy, indifference, inattention, and perseveration in an obsessive compulsive patient taking high doses of fluoxetine. These changes were associated with a decrease in cerebral blood flow in the frontal lobes and changes in neuropsychological tests generally associated with frontal lobe impairment. These clinical manifestations disappeared 4 weeks after discontinuation of fluoxetine.

Publication Types:
  • Case Reports

PMID: 2005077 [PubMed - indexed for MEDLINE]


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