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All Truth passes through Three Stages: First,
it is Ridiculed. Second, it is Violently Opposed... Third, it is Accepted as being Self-Evident.
- Arthur Schopenhauer (1778-1860) By Charly Groenendijk           Back to Side-Effects
The Netherlands                   Back to Safe?
2000 - 2004

 
  Akathisia and Mania  
 

"Who does Not Know the Truth, is simply a Fool...
Yet who Knows the Truth and Calls it a Lie, is a Criminal."
- In "Galileo Galilei" by Berthold Brecht (1898-1956)

Akathisia & Mania -as defined below- can lead to suicidal, aggressive and/or homicidal behaviours.

Protect Your Children Against Bush's (July 2004) Forced U.S. "Mental Health Screening" Program
*** The Federal PPRA Act of 1998
***

Akathisia
Akathisia is a neurologically driven agitation ranging from mild leg tapping, feeling "caffeinated" to severe panic, an extreme manic state and hyper-sensitivity of the nervous system. Symptoms: motor restlessness and specifically, a feeling of muscular quivering; one of the possible complications of treatment with the phenothiazines. Often, the symptoms is of such intensity that it becomes impossible for the patients to sit still day or night, and which is described by them as more difficult to endure than any of the symptoms for which they had been originally treated. Acquaintance with this symptom of akathisia, which often persists for a considerable time after the drug has been withdrawn, is important because it is sometimes mistaken for an agitated depression and wrongly treated.
Source: Psychiatric Dictionary, Fifth Edition, Oxford University Press, 1981

Mania
Mania is an abnormally elated mental state, typically characterized by feelings of euphoria, lack of inhibitions, racing thoughts, diminished need for sleep, talkativeness, risk taking, and irritability. In extreme cases, mania can induce hallucinations and other psychotic symptoms. Hypomania is a term applied to a condition resembling mania. It is characterized by persistent or elevated expansive mood, hyperactivity, inflated self esteem, etc., but of less intensity than mania. Severe mania may have psychotic features.
Source: Blue Cross Blue Shield of Massachusetts http://www.ahealthyme.com/topic/topic100587127

Medical reports, side-effects: AKATHISIA, MANIA, RESTLESSNESS & RESTLESS LEGS SYNDROME
2003 
12/00
 Case/Review Fluoxetine (Prozac) dose-increment related Akathisia in depression
2003 
10/00
 Case/Study Induction of mania in depression by Paxil/Seroxat (paroxetine)
2003 
07/00
 Case/Review Case report Zoloft (Lustral, sertraline)-induced Hypomania: a genuine side-effect
2003 
06/00
 Case/Review Mania associated with Effexor (Efexor, venlafaxine) discontinuation
2003 
04/00
 Case/Review Eroto-Mania induced by Effexor (venlafaxine): a case study
2002 
12/00
 Case/Review Restless Legs Syndrome induced by Remeron (mirtazapine)
2002 
12/00
 Case/Review Worsening of autosomal dominant Restless Legs Syndrome after use Mirtazapine
2002 
11/00
 Case/Review Dysphoric Mania with high-dose Mirtazapine: a case for Norepinephrine Syndrome?
2002 
11/00
 Case/Review Zoloft/Lustral-Induced Akathisia and Dystonia Misinterpreted as a Panic Attack
2002 
07/08
 Case/Review High-dose fluoxetine-induced Mania. Review and case report
2002 
06/22
 Case/Review Akathisia due to the higher dose of fluoxetine -scroll to case 3
2002 
03/04
 Case/Review Remeron (Remergil, mirtazapine)-induced acute Akathisia
2001 
06/00
 Case/Review Mania & Paranoid Ideation following Tramadol-Fluoxetine Combination
1999 
03/02
 Case/Review SSRI's induced Mania in obsessive compulsive disorder
1998 
08/00
 Case/Study Manic behaviors with Prozac (fluoxetine) in three 12- to 18-year-olds with OCD
1998 
08/00
 AnimalStudy Reduced activity of rat dopaminergic neurons in the VTA may explain "Akathisia"
1998 
06/00
 Case/Review Hypomania associated with mirtazapine augmentation of sertraline
1997 
02/00
 No Abstract Mania associated with serotonin selective reuptake inhibitors
1996 
12/00
 Case/Review Restless legs syndrome worsened by Paxil/Seroxat (paroxetine)
1996 
10/00
 Case/Review SSRI Side-Effects: Akathisia, Dystonia, Parkinsonism & Tardive Dyskinesia
1996 
05/00
 No Abstract SSRI-induced Akathisia
1996 
03/04
 Case/Review Akathisia: a review and case report following paroxetine treatment
1995 
09/00
 No abstract Paxil (Seroxat, paroxetine)-induced psychotic mania
1995 
08/00
 Case/Review Antidepressant-induced Mania and Cycle Acceleration: a controversy revisited
1994 
11/00
 Case/Review Antidepressant-associated Mania: a controlled comparison with spontaneous mania
1994 
09/10
 Case/Review Revisiting Fluoxetine: Akathisia & Suicidal Preoccupations
1992 
11/00
 Case/Review Akathisia, Suicidality and Prozac/Sarafem (FLUOXETINE)
1992 
07/00
 Case/Review Prozac (fluoxetine) treatment: Restlessness, Hyperactivity, Agitation, Insomnia
1992 
03/00
 Case/Review Mania associated with Prozac/Sarafem (fluoxetine) treatment in adolescents
1991 
12/00
 Case/Review Prozac-induced Serious Suicide Attempts by 3 patients: the Role of Akathisia
1989 
09/00
 Case/Review Typical Prozac/Sarafem-induced Akathisia: clinical and theoretical implications
1984 
02/00
 Case/Review A case of mania associated with Prozac/Sarafem (fluoxetine)

AKATHISIA & LINK TO SUICIDAL, AGGRESSIVE, HOMICIDAL THOUGHTS/BEHAVIOURS
2003 
04/00
 Case/Review Antisocial Violent Offenders demonstrate Akathisia-like hyperactivity
2001 
08/00
 Case/Review Association between Akathisia and both Suicidality & Depersonalization
1999 
09/00
 Case/Review Delayed Akathisia and Suicidal Attempts
1997 
10/00
 Case/Study Akathisia, a risk factor for Aggressive & Violent Behavior
1997 
00/00
 Case/Review Akathisia as Violence
1994 
09/10
 Case/Review Revisiting Fluoxetine: Akathisia & Suicidal Preoccupations
1992 
11/00
 Case/Review Akathisia, Suicidality and Prozac/Sarafem (FLUOXETINE)
1991 
12/00
 Case/Review Prozac-induced Serious Suicide Attempts by 3 patients: the Role of Akathisia
1990 
00/00
 Case/Review Akathisia and Violence
1987 
09/00
 Case/Review Akathisia been linked to Suicidal & Homicidal Behavior in extreme cases
1986 
06/00
 Case/Trial A case of Suicidal & Homicidal Ideation and Akathisia

Medical reports, side-effects: SUICIDE, SUICIDALITY, SUICIDE ATTEMTPS & SELF-HARM
2004 
06/08
 HealthCanada ZYBAN WARNING: Risk of suicide, self-harm, behavioural/emotional changes
2004 
05/26
 HealthCanada REMERON WARNING: Risk of suicide, self-harm, behavioural/emotional changes
2004 
05/26
 HealthCanada ZOLOFT WARNING: Risk of suicide, self-harm, behavioural/emotional changes
2004 
05/26
 HealthCanada CELEXA WARNING: Risk of suicide, self-harm, behavioural/emotional changes
2004 
05/26
 HealthCanada EFFEXOR WARNING: Risk of suicide, self-harm, behavioural/emotional changes
2004 
05/18
 HealthCanada PROZAC WARNING: Risk of suicide, self-harm, behavioural/emotional changes
2004 
05/18
 HealthCanada PAXIL WARNING: Risk of suicide, self-harm, behavioural/emotional changes
2004 
04/23
 EMEA/EUROPE CPMP/EMEA warning EUROPE: Paxil should not be used in children & adolescents
2003 
00/00
 Case/Review Paxil can cause some individuals to commit homicide and/or suicide
2003 
10/00
 Case/Study Suicide Attempts in Clinical Trials with SSRI's in (MDD) Children
2003 
09/02
 Case/Review Paxil: increased risk of suicidal thoughts, suicide attempts & self-harm in children
2003 
08/22
 Wyeth Effexor/Efexor induces suicidal/homicidal behaviour in children
2003 
06/15
 Case/Review Paxil not for under 18-studies showing higher rates suicidal thoughts & behaviour
2003 
04/00
 Case/Study Clinical Study Dr David Healy: Lines of evidence on Risks of suicide with SSRIs
2001 
03/00
 Case/Study Treatment-Emergent Behavioural Side-Effects in adults with learning disabilities
2001 
01/00
 No abstract PAXIL AND SELF-SCRATCHING
2000 
06/13
 Case/Study Occurrence of Deliberate Self-Harm highest with Fluoxetine (Prozac/Sarafem)
2000 
05/30
 Clinical Trial Use of Sertraline (Zoloft) Linked to Suicidality
1999 
12/00
 Case/Review Deliberate Self-poisoning following Luvox/Fevarin-Neuroleptics combination
1994 
02/00
 Case/Review Fluoxetine and Violent Death in Maryland: violent methods in fluoxetine suicides
1995 
00/00
 Case/Review Fluoxetine: increased suicidal ideation and/or agitation have been reported
1992 
11/00
 Case/Review Irritability, Self-Damage by Cutting & Violent Intense Suicidal, Paranoid Ideation
1991 
12/00
 Case/Review Serious suicide attempts by 3 patients during treatment Fluoxetine: Akathisia
1991 
03/00
 Case/Review Emergence of Self-destructive phenomena in children during Prozac treatment
1990 
02/00
 Case/Review Emergence of Intense Suicidal Preoccupation during Prozac (Sarafem) treatment

MEDIA ARTICLES
2004 
02/07
 Indianapolis Star CYMBALTA (DULOXETINE) SUICIDE -TRACI R. JOHNSON, 19
2004 
02/03
 FDA US Antidepressant Strengthened Warnings Pediatric Suicidality Risk
2004 
02/03
 Washingt.Post FDA Links Antidepressants, Youth Suicide Risk Part2
2004 
01/26
 Th.J. Moore Antidepressant Drugs and Suicidal/Aggressive Behaviors
2004 
01/26
 Ps. Networker Kids, Meds & Suicide -dangerous side effects SSRIs
2004 
01/21
 USA Today Antidepressants and suicide
2004 
01/04
 SF Chronicle Suicide Effect? What parents aren't being told about their kids' antidepressants
2003 
12/27
 NWI Times Hidden adverse reactions to antidepressants possible downside to misdiagnosis
2003 
10/28
 WebMDHealth FDA Warns of Drug-Suicide Risk in Kids
2003 
10/27
 Washingt.Post FDA Warns Doctors About pot. Higher Suicide Risk SSRIs under 18
2003 
10/27
 FDA US FDA emphasizes that anti-depressants must be used with caution
2003 
10/10
 FDA US Antidepressant Reports Of Suicidality In Children Topic Of FDA Meeting In Feb.
2003 
09/20
 TheGuardian 50,000 children on antidepressants-fears drug made youngsters suicidal
2003 
08/07
 NewYorkTimes Debate Resumes on Safety Antidepressants Part2 Part3
1999 
11/30
 PR Newswire Survey Antidepressants shows troublesome side effects & modest improvement
1999 
09/18
 Dr Julian Whitaker Akathisia: The Scourge of Prozac

*  Interruption/Discontinuation of SSRIs Associated with Somatic and Psychological Symptoms
*  Prozac can bring on Impulse to Suicide Related Link(1) Related Link(2)
*  Use of Sertraline (Zoloft/Lustral) Linked to Suicidality

(SSRI/SSNRI) Antidepressants
Antidepressant 
Side-Effects
  Buspirone: Buspar or Neurosine
Antidepressant 
Side-Effects
  Citalopram: Celexa or Cipramil
Antidepressant 
Side-Effects
  Escitalopram: Cipralex or Lexapro
Antidepressant 
Side-Effects
  Duloxetine: Cymbalta
Antidepressant 
Side-Effects
  Venlafaxine: Effexor or Efexor
Antidepressant 
Side-Effects
  Paroxetine: Paxil, Seroxat, Aropax or Pexeva
Antidepressant 
Side-Effects
  Fluoxetine: Prozac or Sarafem
Antidepressant 
Side-Effects
  Mirtazapine: Remeron or Remergil
Antidepressant 
Side-Effects
  Nefazodone: Serzone or Dutonin
Antidepressant 
Side-Effects
  Trazodone: Trazodone or Desyrel
Antidepressant 
Side-Effects
  Bupropion: Wellbutrin or Zyban
Antidepressant 
Side-Effects
  Sertraline: Zoloft or Lustral
Antidepressant 
Side-Effects
  ALL SSRI's: SSRI & SSNRI Antidepressants

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