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All Truth passes through Three Stages: First,
it is Ridiculed. Second, it is Violently Opposed... Third, it is Accepted as being Self-Evident.
- Arthur Schopenhauer (1778-1860) By Charly Groenendijk           Back to Side-Effects
The Netherlands
2000 - 2009

 
  SSRI & SSNRI Antidepressants Side-Effects  
 

"Who does Not Know the Truth, is simply a Fool...
Yet who Knows the Truth and Calls it a Lie, is a Criminal."
- In "Galileo Galilei" by Berthold Brecht (1898-1956)

Take notice that also non SSRI antidepressants (and even Ritalin) may interact (primary or secondary) with the serotonergic (or serotoninergic) system in the brain. Every medication -especially SSRI antidepressants- boosting serotonin activity in the brain, has potential to induce the very dangerous and potentially fatal hyperserotonergic state of the Serotonin Syndrome.
SSRI & SSNRI Antidepressants side-effects, neurological damage
Selective Serotonin / Nor-Epinehrine Re-Uptake Inhibitors
Go to Introduction Antidepressants Negative personality, perception & physical changes
Go to Antidepressant Casualties in the Media Aggression, Homicide, Suicide & Self-Harm
Go to Recent Media Articles (SSRI) Antidepressants Pharmaceutical & FDA Fraud in 2004
Tardive Dyskinesia/Dystonia, Parkinsonism & Akathisia
SSRI & SSNRI antidepressants induced side-effects (Iatrogenic Extrapyramidal Symptoms) are
recognized to be similar to Neuroleptic (anti-psychotic) induced side-effects. These side-effects are known as Tardive Dyskinesia/Dystonia (severe body movement disorder, mostly permanent), Parkinsonism (a sign of future Parkinson's disease) and Akathisia (a Neurological driven severe mania/agitation that can lead to suicidality, suicide attempts, self-harm & suicide). It is well documented in the medical literature that these neuroleptic induced side-effects refer to damage at dopaminergic neurons in the "motor system" of the
"Basal Ganglia", a structure deep in the "Limbic System" of the brain. 1, 2, 3, 4, http://www.emedicine.com/EMERG/topic338.htm (scroll down)

Serotonin Syndrome
The Serotonin Syndrome is a potentially lethal condition caused by excessive serotonergic activity. It is a very dangerous and a potentially fatal side effect of the serotonergic enhancing drugs such as SSRI & SSNRI antidepressants and is diagnosed by the presence of at least 3 of 10 symptoms: mental status changes (confusion, hypomania), agitation, myoclonus, hyperreflexia, diaphoresis, shivering, tremor, diarrhea, incoordination, and fever. This "hyperserotonergic" toxic condition requires heightened clinical awareness in order to prevent, recognize, and treat the condition promptly. Promptness is vital because, as we just mentioned, the serotonin syndrome can be fatal and death from this side effect can come very rapidly. The Serotonin syndrome is brought on by excessive levels of serotonin and is difficult to distinguish from the "Neuroleptic Malignant Syndrome" because the symptoms are so similar. The "Neuroleptic Malignant Syndrome" is a serious condition brought on by the use of neuroleptic drugs (anti-psychotics).
Source: Prozac: Panacea or Pandora? by Dr Ann Blake Tracy http://members.aol.com/atracyphd/syndrome.htm
Source: Journal of Clinical Psychiatry

Antidepressant induced neurological and/or physical toxicity (body and/or brain damage) either as a result of prolonged inhibition of P450-2D6 liver-enzymes, or as a result of impairing serotonin metabolism, can take on many forms as described below. A few examples are:   Hyperserotonemia, such as the lifethreatening condition the Serotonin Syndrome, Epileptiform Discharges, Epileptic Seizures and/or Epilepsy, Hypoglycaemia/Hyperglycemia (Low/Elevated Blood Sugar Imbalance), Stroke/Hemorrhagic Syndromes, Frontal Lobe Syndrome, Tardive Dyskinesia/Dystonia, Parkinsonism, Akathisia, Mania, etc...

MEDICAL REPORTS OF SSRI/SSNRI ANTIDEPRESSANT INDUCED (IATROGENIC) SEVERE SYMPTOMS:

Medical reports, side-effects: HYPOGLYCEMIA (Low blood sugar), HYPERGLYCEMIA (High blood sugar, diabetes)
2004 
04/00
 Animal Study Hyperglycemia induced by acute central fluoxetine (Prozac) administration
2003 
07/00
 Case/Review Hypertriglyceridemia, Acute Pancreatitis & Diabetic Ketoacidosis with Mirtazapine
2003 
06/00
 Case/Review Zoloft/Lustral-induced Hyperglycemia: case report
2001 
11/00
 Case/Review Sertraline-induced Hypoglycemia
2001 
01/00
 Animal Study Fluoxetine (Prozac) caused significant hyperglycemia after injection into the blood...
2000 
03/00
 Case/Review Loss of Hypoglycemia Awareness in Diabetic Adolescent during Fluoxetine therapy
1999 
10/15
 Animal Study SSRI's Fluoxetine (Prozac) & fluvoxamine (Luvox) induced hyperglycemia...
1999 
04/00
 Case/Review Hypoglycemia associated with high doses of sertraline & sulphonylurea compound
1997 
11/00
 Case/Review Baby Prozac (withdrawal) side-effects: Hyperglycaemia (High blood sugar, Diabetes)
1996 
11/00
 No Abstract Suggestive episodes of hypoglycemia related to fluoxetine (Prozac, Sarafem)
1996 
11/01
 Case/Review Hyperglycemia Associated with Paroxetine
1996 
03/00
 No Abstract Hypoglycemia associated with the use of fluoxetine (Prozac)

Medical reports: URINARY INCONTINENCE, DERMATOLOGIC (Skin) PROBLEMS, OCULAR (Eyes) DISTURBANCES
2003 
05/00
 Case/Review Bupropion-induced Rash with Eosinophilia & Systemic Symptoms Syndrome
2002 
09/00
 Case/Review Mirtazapine associated with Significant Weight Gain
2002 
06/00
 Case/Review Generalized Pustular & Erythrodermic Psoriasis associated with Bupropion
2002 
06/00
 Case/Review Zoloft/Lustral-induced Urinary Incontinence
2002 
05/00
 Case/Review Urinary Incontinence with mirtazapine
2002 
04/00
 Case/Review Two cases of rash induced specifically by paroxetine
2001 
00/00
 Case/Review Bruxism (Teeth Grinding)
2001 
12/00
 Case/Review Photopigmentation
2001 
07/00
 Case/Review Venlafaxine-Induced Hair Loss
2001 
06/07
 Case/Review Cutaneous Lesions during SSRI's therapy: 2 cases
2001 
05/00
 Case/Review Mitrazapine-associated Palinopsia
2001 
03/00
 Case/Review Cutaneous Vasculitis (severe dermatologic side-effects) Induced by Paroxetine
2000 
12/00
 Case/Review Serotonergic antidepressants and Urinary Incontinence
2000 
06/00
 No abstract Acute Angle Closure Glaucoma presenting in a Young Patient after paroxetine
2000 
04/02
 Case/Review Severe Alopecia (massive hair loss) due to Paxil/Seroxat (paroxetine) therapy
1999 
10/00
 Case/Review Effexor-induced Bruxism (Teeth Grinding)
1999 
07/08
 Case/Review Hair loss associated with paroxetine treatment: a case report
1998 
03/04
 Case/Review Increased Ocular Pressure in 2 patients treated with venlafaxine
1997 
05/10
 Case/Review Acute angle closure glaucoma associated with paroxetine
1997 
03/00
 Case/Review Bilateral acute angle closure glaucoma after administration of paroxetine
1996 
11/00
 Case/Review Paxil/Seroxat (paroxetine) induced bruxism (teethgrinding)

Medical reports: PAIN & NUMBNESS, SWELLINGS, SEXUAL (ORGAN) PROBLEMS, HORMONAL IMBALANCES
2002 
00/00
 Case/Study Abstract: Sexual Dysfunction & Newer Antidepressants
2002 
10/00
 Case/Review Effexor (& other antidepressants) -induced Sexual Dysfunction
2002 
10/00
 Case/Review Antidepressant-induced sexual dysfunction
2002 
09/00
 Case/Review Long-term side effects of newer-generation SSRI antidepressants
2002 
07/00
 Case/Review Paxil/Seroxat (paroxetine)-induced vaginal anaesthesia
2002 
05/00
 Case/Review Effexor/Efexor (venlafaxine)-associated Vaginal Bleeding
2002 
04/00
 Case/Review Remeron (mirtazapine) associated with Higher Rates for Risk of Sexual Dysfunction
2002 
04/00
 Case/Review Celexa/Cipramil (citalopram)-induced Priapism
2001 
00/00
 Case/Review Incidence of sexual dysfunction associated with antidepressant agents: SSRI's
2001 
12/00
 Case/Review Remeron-induced Arthralgia (joint pain, stiffness) & Myalgia (muscle pain, viral)
2001 
08/00
 Case/Review Flushing/Return of Hot Flashes in Menopausal Woman Taking Effexor (venlafaxine)
2001 
06/07
 Case/Review Cutaneous adverse effects: painful papular & purpuric erythema with Paxil/Seroxat
2000 
00/00
 Case/Review Abstract: SSRIs & Sexual Dysfunction (Paxil, Zoloft, Effexor)
2000 
00/00
 Case/Review Prozac (fluoxetine)-induced Anaesthesia of Vagina and Nipples
2000 
10/00
 Case/Review Sexual Dysfunctions induced by Celexa/Cipramil & SSRI's
2000 
09/00
 Case/Review Reduced Testosterone Level in Effexor (venlafaxine) treated patient
2000 
04/00
 Case/Review Effexor (venlafaxine)-induced Painful Ejaculation
2000 
04/00
 Case/Review Abstract: SSRIs & Sexual Dysfunction (Paxil, Zoloft, Effexor)
2000 
03/00
 Case/Review Prozac/Sarafem (fluoxetine) and grossly swollen muscles & oedematous
1999 
05/00
 Case/Review Paxil/Seroxat (paroxetine)-induced Anorgasmia in 41-year-old Caucasian woman
1998 
06/00
 Case/Review Sexual Dysfunction associated with Remeron/Remergil (mirtazapine): a case report
1997 
03/00
 Case/Review Celexa/Cipramil (citalopram)-induced Clitoral Priapism
1996 
05/00
 Case/Review Priapism (painful persistent erection of penis) caused by Paxil/Seroxat (paroxetine)
1996 
01/00
 Case/Review Celexa/Cipramil (citalopram)-induced Anorgasmia

Medical reports, side-effects: HYPONATREMIA & SIADH
2004 
02/09
 Case/Study Paroxetine-induced hyponatremia in older adults: a 12-week prospective study
2004 
01/16
 Case/Review Severe Symptomatic Hyponatremia
2003 
00/00
 Case/Review Mirtazapine-induced Hyponatraemia
2003 
09/00
 Case/Study Hyponatremia in the elderly due to inappropriate secretion of antidiuretic hormone
2003 
06/15
 Case/Review Hyponatraemia with SSRI's
2002 
00/00
 Case/Review Paroxetine Associated Hepatotoxicity: Report of 3 Cases & Review of the Literature
2002 
00/00
 Case/Review Severe Hyponatraemia with Coma & Seizure
2002 
10/00
 Case/Review Syndrome of Inappropriate Secretion of Antidiuretic Hormone (SIADH)
2002 
03/00
 Case/Review Hyponatremia & SIADH associated with Sertraline and Fluoxetine: a case report
2002 
03/00
 Case/Review Hyponatremia associated with Zoloft/Lustral & Prozac/Sarafem
2002 
03/00
 Case/Review Hyponatraemia in elderly psychiatric patients treated with SSRIs & Effexor
2001 
05/00
 Case/Review Venlafaxine has a stronger association with Hyponatraemia
2001 
02/00
 Case/Review Severe Symptomatic Hyponatremia
2000 
03/02
 Case/Review SIADH with Epileptic Seizures and Coma in fluoxetine therapy
1999 
00/00
 Case/Review Severe life-threatening hyponatremia during paroxetine therapy
1999 
03/00
 Case/Review Severe Hyponatremia during treatment with fluoxetine
1998 
06/00
 Case/Review Sertraline-assoc. Syndrome of Inappropriate Antidiuretic Hormone (SIADH)
1998 
01/00
 Case/Review Hyponatremia with venlafaxine
1998 
01/00
 Case/Review Hyponatremia associated with paroxetine
1997 
00/00
 Case/Review Syndrome of Inappropriate Secretion of Antidiuretic Hormone in 2 elderly women
1997 
06/00
 Case/Review Syndrome of Inappropriate ADH Secretion (SIADH) attributed to venlafaxine
1996 
11/25
 Case/Review SSRI's: Hyponatremia by Schwartz-Bartter Syndrome
1996 
09/01
 Case/Review Hyponatremia & SIADH associated with SSRI's: a review of spontaneous reports
1996 
07/00
 Case/Review The role of sertraline in a patient with Recurrent Hyponatremia
1996 
04/00
 Case/Review Fluoxetine: Syndrome of Inappropriate Secretion of Antidiuretic Hormone (SIADH)

Medical reports, side-effects: SUICIDE, SUICIDALITY, SUICIDE ATTEMTPS & SELF-HARM
2004 
09/14
 FDA US Antidepressant "BLACK BOX WARNING" On Suicidality Risk Recommended
2004 
08/26
 FDA US New Warning Required: Antidepressants Induced Suicide in Children & Adults
2004 
08/20
 FDA US FDA Update Review SSRI's: data suggestive of increased suicidality risk
2004 
06/08
 HealthCanada ZYBAN WARNING: Risk of suicide, self-harm, behavioural/emotional changes
2004 
06/03
 Health Canada Stronger warnings for SSRI's & other anti-depressants
2004 
05/26
 HealthCanada REMERON WARNING: Risk of suicide, self-harm, behavioural/emotional changes
2004 
05/26
 HealthCanada ZOLOFT WARNING: Risk of suicide, self-harm, behavioural/emotional changes
2004 
05/26
 HealthCanada CELEXA WARNING: Risk of suicide, self-harm, behavioural/emotional changes
2004 
05/26
 HealthCanada EFFEXOR WARNING: Risk of suicide, self-harm, behavioural/emotional changes
2004 
05/18
 HealthCanada PROZAC WARNING: Risk of suicide, self-harm, behavioural/emotional changes
2004 
05/18
 HealthCanada PAXIL WARNING: Risk of suicide, self-harm, behavioural/emotional changes
2004 
04/23
 EMEA/EUROPE CPMP/EMEA warning EUROPE: Paxil should not be used in children & adolescents
2004 
03/22
 FDA US FDA: Cautions for Use of Antidepressants in Adults & Children
2004 
03/22
 FDA US FDA: Worsening Depression & Suicidality with Antidepressant Medications
2004 
03/11
 TGA AUS TGA: Use of SSRI antidepressants in children and adolescents
2004 
02/03
 FDA US Antidepressant Strengthened Warnings Pediatric Suicidality Risk
2003 
00/00
 Case/Review Paxil can cause some individuals to commit homicide and/or suicide
2003 
12/10
 MHRA/CSM UK SSRI antidepressants not for under 18 years in United Kingdom / MHRA site
2003 
10/00
 Case/Study Suicide Attempts in Clinical Trials with SSRI's in (MDD) Children
2003 
09/00
 Case/Review Antidepressants (SSRI's) and suicide: risk-benefit conundrums
2003 
09/02
 Case/Review Paxil: increased risk of suicidal thoughts, suicide attempts & self-harm in children
2003 
08/22
 Wyeth Effexor/Efexor induces suicidal/homicidal behaviour in children
2003 
06/15
 Case/Review Paxil not for under 18-studies showing higher rates suicidal thoughts & behaviour
2003 
04/00
 Case/Study Clinical Study Dr David Healy: Lines of evidence on Risks of suicide with SSRIs
2001 
03/00
 Case/Study Treatment-Emergent Behavioural Side-Effects in adults with learning disabilities
2001 
01/00
 No abstract PAXIL AND SELF-SCRATCHING
2000 
06/13
 Case/Study Occurrence of Deliberate Self-Harm highest with Fluoxetine (Prozac/Sarafem)
2000 
05/30
 Clinical Trial Use of Sertraline (Zoloft) Linked to Suicidality
1999 
12/00
 Case/Review Deliberate Self-poisoning following Luvox/Fevarin-Neuroleptics combination
1994 
02/00
 Case/Review Fluoxetine and Violent Death in Maryland: violent methods in fluoxetine suicides
1995 
00/00
 Case/Review Fluoxetine: increased suicidal ideation and/or agitation have been reported
1992 
11/00
 Case/Review Irritability, Self-Damage by Cutting & Violent Intense Suicidal, Paranoid Ideation
1991 
12/00
 Case/Review Serious suicide attempts by 3 patients during treatment Fluoxetine: Akathisia
1991 
03/00
 Case/Review Emergence of Self-destructive phenomena in children during Prozac treatment
1990 
02/00
 Case/Review Emergence of Intense Suicidal Preoccupation during Prozac (Sarafem) treatment

Medical reports, side-effects: MENTAL STATE, PERCEPTUAL, EMOTIONAL & PSYCHOLOGICAL CHANGES
2004 
03/00
 Case/Review Hallucinations with zolpidem and fluoxetine in an impaired driver
2003 
10/00
 No abstract Visual and auditory hallucinations with excessive intake of paroxetine
2003 
07/00
 Case/Review A case report of Paranoid Delusion with venlafaxine use
2003 
07/22
 Case/Review Bupropion: Tremors, Agitation, Confusion, Insomnia & Rash
2003 
04/00
 Case/Review Venlafaxine and Increased Aggression in a female with autism
2002 
09/00
 Case/Review Panic Attacks
2002 
04/00
 No abstract Pathologic laughter associated with paroxetine treatment
2002 
01/14
 Case/Review Acute Psychosis after Administration of Bupropion Hydrochloride (Zyban)
2001 
00/00
 Case/Review An Organic Psychosis due to a venlafaxine-propafenone interaction
2001 
02/00
 Case/Review Visual hallucination and tremor induced by sertraline and oxycodone
2000 
09/00
 Case/Review Melancholic Depression during concurrent olanzapine and fluoxetine
2000 
07/00
 Case/Review Occurrence of Mirtazapine-induced Delirium in organic brain disorder
2000 
07/08
 Case/Review Onset of psychotic symptoms & pseudoneurotic schizophrenia with paroxetine
2000 
05/06
 Case/Review Sertraline-induced Panic Attacks
2000 
02/07
 Case/Review Zoloft/Lustral: Wrong Drug for Panic
1999 
00/00
 Case/Review Postoperative delirium indicating an adverse drug interaction involving paroxetine
1998 
04/01
 Case/Review Hallucinations as a Side Effect of "Venlafaxine"(Effexor) Related Link
1997 
00/00
 Case/Review Toxic Delirium & general Tonic-Clonic Seizure with Prozac & low dose Trazodone
1997 
11/00
 Case/Review Psychosis during chronic levodopa therapy triggered by Mirtazapine
1997 
03/00
 Case/Review Sertraline and Psychotic Symptoms: a case series
1996 
00/00
 Case/Review Nightmares and hallucinations after long-term intake of tramadol & Paxil/Seroxat
1993 
12/00
 Case/Review Acute Hyperkinetic Delirium during fluoxetine treatment. A case report
1992 
12/00
 Case/Review Severe extra pyramidal side effects associated with paroxetine
1992 
07/00
 Case/Study Fluoxetine in autistic disorder: restlessness, hyperactivity, agitation, insomnia...
1982 
09/00
 Case/Review Perceptual Changes with Bupropion

Medical reports, side-effects: MENTAL & PHYSICAL SIDE EFFECTS OF WITHDRAWAL/DISCONTINUATION
2004 
02/00
 Case/Review A Case Report of Mania Related to Discontinuation of Wellbutrin (bupropion)
2003 
12/00
 Case/Review Premature Ejaculation associated with Celexa (Cipramil, citalopram) withdrawal
2003 
07/12
 Case/Review Withdrawal symptoms in Baby after exposure to venlafaxine during pregnancy
2003 
07/08
 Case/Review Severe Headache with venlafaxine withdrawal
2003 
05/00
 Case/Review Shock-like Sensations during Venlafaxine Withdrawal
2003 
05/00
 Case/Review Antidepressant withdrawal-induced Mania in patients with mood disorders
2002 
00/00
 Case/Review Venlafaxine -Long Term Adverse Effects
2002 
11/00
 Case/Review Paxil/Seroxat usage patterns as risk factors for hospitalization
2002 
07/00
 Case/Review Discontinuation/Withdrawal Reactions associated with Effexor (venlafaxine)
2002 
06/00
 Case/Review Delirium during Withdrawal of Effexor
2002 
02/02
 Brit.Med.J. Withdrawal from Paxil (Seroxat, paroxetine) is Severe Warns FDA
2001 
00/00
 Case/Review SSRI-Antidepressant Discontinuation Syndromes
2001 
07/00
 Case/Review Withdrawal Reactions with Effexor (venlafaxine) presenting as stroke
2001 
04/11
 Medscape Antidepressant Discontinuation Syndromes: Common & Under-Recognised
2000 
05/00
 Case/Review SSRI Discontinuation Syndrome/Withdrawal: proposed diagnostic criteria
2000 
04/15
 Case/Review Persistent Adverse Neurological Effects following SSRI Discontinuation
2000 
04/01
 Case/Study Altered Serotonergic Function [as in withdrawal] & Aggressive Behavior
2000 
03/00
 Case/Review Discontinuation/Withdrawal Reactions associated with Effexor (venlafaxine)
1999 
07/00
 Case/Review Selective serotonin reuptake inhibitor Discontinuation/Withdrawal Symptoms
1998 
11/09
 Case/Review Antidepressant Discontinuation-Related Mania also in Bipolar Depression
1998 
10/00
 No Abstract Discontinuation Symptoms and SSRIs
1998 
09/19
 Case/Review Discontinuation/Withdrawal Reactions associated with Effexor (venlafaxine)
1998 
04/00
 Case/Review Discontinuation/Withdrawal Reactions associated with Effexor (venlafaxine)
1998 
02/00
 Case/Review Akathisia in withdrawal reactions Effexor (venlafaxine)
1997 
12/00
 Case/Review Discontinuation/Withdrawal Reactions associated with Effexor (venlafaxine)
1996 
10/00
 Case/Review Serotonin reuptake inhibitor withdrawal
1996 
03/00
 Case/Review Sertraline Withdrawal in two brothers: a case report
1995 
01/00
 Case/Review Reversible Delirium after discontinuation of Prozac (fluoxetine)

Medical reports, side-effects: (SUICIDE OVERDOSE)-TOXICITY & DEATH
2003 
12/00
 Case/Review Fatality related to a 30-g venlafaxine overdose
2003 
11/00
 Case/Review Bupropion-overdose: Patient suffered from Prolonged Symptoms & Seizures
2003 
08/00
 Case/Review Cardiotoxicity & Late Onset Seizures with overdose
2003 
07/08
 Case/Review Bupropion overdose: QTc Prolongation and its clinical significance
2003 
05/00
 Case/Review Effexor/Efexor is more likely to cause serotonin toxicity in overdose
2002 
11/00
 Case/Review Cardiotoxicity following Wellbutrin/Zyban overdose
2002 
10/04
 Case/Review Deaths, Arrhythmias & Seizures in Effexor (venlafaxine) overdose
2002 
08/00
 Case/Review Venlafaxine Poisoning complicated by a late rise in creatine kinase
2002 
07/00
 Case/Review Postmortem Concentrations of Citalopram
2002 
01/11
 Case/Review Toxicity of Wellbutrin/Zyban in deliberate self-poisoning in adults
2002 
01/00
 Case/Review Wellbutrin/Zyban overdose: Severe Cardiac Arrhythmias, Hallucinations & Seizures
2002 
01/00
 Case/Review Wellbutrin/Zyban: Significant Neurological & Cardiovascular Toxicity in overdose
2001 
10/00
 Case/Review Determined to be incidental finding to ultimate Cause of Death in 11 Cases
2001 
05/06
 Case/Review QTc Interval Prolongation associated with overdose
2001 
04/00
 Case/Review 14-year-old boy who ingested 1.5 to 3 g of Bupropion in a Suicide Attempt
2001 
01/16
 Case/Review Conduction Disturbances Associated with Venlafaxine-overdose
2000 
10/00
 Case/Review An unusual multiple drug Fatal Intoxication case involving citalopram
2000 
09/00
 Case/Review Death from asthma associated with sertraline overdose
2000 
07/00
 Case/Review Suicide Attempt Overdose: Severe Sinus Bradycardia; Pacemaker
2000 
05/00
 Case/Review Antidepressants can result in Toxicity and Death through serotonergic excess
2000 
05/00
 No abstract Association of paroxetine with suicide attempt in obsessive-compulsive disorder
2000 
05/00
 Case/Review Sertraline can result in Toxicity and Death through serotonergic excess
2000 
04/00
 Case/Review Child, 9; liver cytochrome P-450 2D6 deficiency; Prozac-related death
1999 
07/08
 Case/Review A young nurse commits suicide with doxepin and paroxetine (Paxil/Seroxat)
1999 
05/00
 Case/Review Effexor/Efexor: Significant Cardiovascular & Neurological Toxicity in overdose
1998 
11/00
 Case/Review Autopsy cases in which Citalopram (Toxicity) alone was the Cause of Death
1998 
09/10
 Case/Review Tonic Clonic Seizures & Tachycardia induced by fluoxetine (Prozac) overdose
1998 
06/00
 Case/Review Paxil suicide attempt by 83-year-old: hyponatremia, confusion, muscle spasms...
1997 
00/00
 Case/Review Fatal Bupropion-overdose
1997 
02/00
 Case/Review Seizure resulting from a venlafaxine overdose
1996 
07/08
 Case/Review Two Fatal Cases of Venlafaxine Poisoning
1995 
00/00
 Case/Review A case report of venlafaxine-overdose Toxicity
1995 
08/00
 Case/Review Seizure after isolated fluoxetine-overdose
1994 
03/00
 Case/Review Bupropion-overdose: Grand Mal Seizures & Sinus Tachycardia
1991 
09/00
 Case/Review Unexpected Deaths in depressed medical inpatients treated with Fluoxetine
1989 
00/00
 Case/Review Fluoxetine-overdose: Flu-like Symptoms, Urticaria & Angioedema
1982 
03/00
 AnimalStudy High dose toxicity in Dogs: Severe Convulsive Attacks, Sinus Tachycardia & Death

OTHER OBSERVATIONS & COMPLICATIONS: CASE REPORTS, REVIEWS & STUDIES
2004 
07/14
 FDA Warning FDA warning Cipramil (citalopram): Aluminum Toxicity in interaction with linezolid
2004 
03/00
 Case/Review Bupropion and its active metabolites are present in breast milk
2004 
02/00
 Case/Review SSRI's not so selective: Increased Brain GABA Concentrations
2003 
10/00
 Case/Review Adverse event reporting with SSRI antidepressants - The Weber effect
2002 
12/00
 Case/Review Observational study Sertraline: over 100 different unlabelled adverse events
2002 
10/00
 Case/Study Risk factors for falls during Paxil/Seroxat treatment of late-life depression
2002 
09/00
 Case/Review Pharmacologic management of SSRI-induced side effects: survey of psychiatrists
2002 
09/03
 Case/Review Drug safety without borders: Concerns about Wellbutrin/Zyban
2002 
06/03
 Case/Review Perhexiline Toxicity related to Citalopram use
2002 
05/00
 AnimalStudy Impaired Spatial Learning in the Morris water maze induced by SSRI's in rats
2002 
02/00
 Case/Review SSRI's & cytochrome P-450 liver enzyme mediated drug-drug interactions: update
2001 
02/00
 Case/Review Reversible Galactorrhea & Prolactin Elevation related to fluoxetine use
2000 
00/00
 Sev. Studies Iatrogenic (drug induced) side-effects from Antidepressants
1999 
03/00
 Case/Review SSRI's Noncompetitively Inhibit Nicotinic Acetylcholine Receptor Function
1998 
09/00
 Case/Review SSRI's: differences in inhibition of the cytochrome P450 liver enzyme system
1997 
12/21
 Moore/Study Hard to Swallow: Serzone and Effexor
1997 
09/00
 Case/Review Excretion of Citalopram in Breast Milk
1997 
07/00
 Case/Review Paroxetine and galactorrhea (breasts leaking white fluid - possible cancer when red)
1996 
08/12
 Case/Review Placebo Effect Accounts for 50% Improvement in Patients on Antidepressants
1993 
00/00
 Case/Review Fluoxetine: Adverse Effects and drug-drug Interactions
1993 
11/00
 Case/Review SSRI-associated nocturnal Bruxism (teeth-grinding) in 4 patients
1992 
09/00
 Case/Review Effect of SSRI's on cytochrome P450 (CYP2D6) activity in human liver microsomes

 Antidepressant Neurological Side-Effects: Addiction & Withdrawal
 Antidepressant Neurological Side-Effects: Akathisia & Mania (Suicide & Aggression)
 Antidepressant Neurological Side-Effects: Serotonin Syndrome
 Antidepressant Neurological Side-Effects: Toxicity & Brain Damage
 Antidepressant Neurological Side-Effects: "Anecdotal" Reports -Personal Experiences

 Antidepressants: How To Wean/Taper Off
 Antidepressants: How to Survive a Negative Reaction
 Antidepressants: Conquering Depression and Anxiety

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