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1: Ned Tijdschr Geneeskd. 1997 Mar 15;141(11):540-2. Related Articles, Links

[Severe hepatitis attributed to paroxetine (Seroxat)]

[Article in Dutch]

de Man RA.

Academisch Ziekenhuis Rotterdam-Dijkzigt, afd. Maag-, Darm- en Leverzieklen.

A 52-year-old man suffering from chronic hepatitis B related liver cirrhosis was treated for depression with paroxetine (Serotax) 5 mg and subsequently 15 mg once daily. A severe hepatitis with liver failure (jaundice, hypoalbuminaemia, edemas, and ascites) developed. After the drug was withdrawn the patient recovered completely. The adverse reaction may be explained by a change in the pharmacokinetics of the drug caused by the liver cirrhosis. Caution is required in prescribing long-term paroxetine therapy for patients with documented liver cirrhosis. The liver function should be monitored and administration of the drug should be discontinued when functional disturbances are noticed.

Publication Types:
  • Case Reports

PMID: 9190513 [PubMed - indexed for MEDLINE]


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