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Revisiting fluoxetine (Proxac) and
suicidal preoccupations.
Tueth
MJ.
Department of Psychiatry, University of Florida,
Gainesville 32608.
Several reports were published in the
psychiatric literature in 1990 and 1991 documenting fluoxetine (Prozac)
causing patients to consider or attempt suicide. During the following 2
years, retrospective studies appeared in the medical literature that
seemed to indicate that suicidal preoccupation was not related to the
antidepressant fluoxetine (Prozac) but was probably a symptom of the
depressive illness. Recent studies have suggested, however, that
fluoxetine (Prozac) may in fact lead to suicidal behavior because the
drug appears to adversely affect serotonergic neuronal discharge and
induce an akathisia-like extrapyramidal reaction. While fluoxetine
(Prozac) has a very favorable side effect profile compared to the
tricyclic antidepressants, it may cause akathisia and induce a small
subset of patients to consider or attempt suicide.
PMID: 7989697
[PubMed - indexed for MEDLINE]
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