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1: Biol Psychiatry. 1990 Sep 15;28(6):518-21. Related Articles, Links

Fluoxetine and neuroleptic malignant syndrome.

Halman M, Goldbloom DS.

Department of Psychiatry, Toronto General Hospital, University of Toronto, Canada.

The authors present a case report of neuroleptic malignant syndrome (NMS) in a patient commencing treatment with fluoxetine alone who had previously been treated with several antipsychotic and antidepressant combinations. On reviewing the literature on the pathogenesis of NMS, the authors hypothesize a facilitative role of the neurotransmitter serotonin (5-HT) in conjunction with central dopaminergic blockade in the precipitation of NMS.

Publication Types:
  • Case Reports

PMID: 2223920 [PubMed - indexed for MEDLINE]


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