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Nightmares and hallucinations
after long-term intake of tramadol combined with
Devulder J, De Laat M, Dumoulin K,
Renson A, Rolly G.
Department of Anesthesia and Pain Clinic
Gent University Hospital, Belgium.
Tramadol is a weak opioid with
effects on adrenergic and serotonergic neurotransmission that is used to
treat cancer pain and chronic non malignant pain. This drug was
initiated in association with paroxetine and dosulepine hydrochloride in
a tetraparetic patient with chronic pain. Fifty-six days after
initiation of the treatment the patient presented hallucinations that
only stopped after the withdrawal of psycho-active drugs and tramadol.
The case report questions the long term use of pain killers combined
with psycho-active drugs in chronic non malignant pain, especially if
pain is under control.
PMID: 8766220 [PubMed - indexed for