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| The International Journal of Neuropsychopharmacology (2003),
6:89-90 Cambridge University Press Copyright © 2003 Collegium Internationale Neuropsychopharmacologicum DOI 10.1017/S1461145703003274
Mania associated with venlafaxine discontinuation
Abstract
Switch to hypomania, mania, or rapid-cycling has been reported with virtually every class of antidepressant medication (Montgomery et al., 2000). Mania and hypomania have been also reported as a result of antidepressant discontinuation in bipolar disorder, whether or not patients were also taking a mood stabilizer (Goldstein et al., 1999). Venlafaxine-associated mania (Shulman et al., 2001; Stoner et al., 1999) and a paradoxical shift to mania upon its discontinuation despite adequate lithium treatment have been reported (Goldstein et al., 1999). We describe here, however, a case which has some interesting features by virtue of its longitudinal development. (Received July 22 2002)(Reviewed October 30 2002) (Revised November 27 2002) (Accepted December 3 2002) Correspondence: c1 Dr G. A. Fava, Department of Psychology, University of Bologna, Viale Berti Pichat 5, 40127 Bologna, Italy. Tel.: +39-051-2091339 Fax: +39-051-243086 E-mail: fava@psibo.unibo.it |
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