Text Version
Entrez PubMed
Overview
Help | FAQ
Tutorial
New/Noteworthy
E-Utilities
PubMed Services
Journals Database
MeSH Database
Single Citation Matcher
Batch Citation Matcher
Clinical Queries
LinkOut
Cubby
Related Resources
Order Documents
NLM
Gateway
TOXNET
Consumer
Health
Clinical Alerts
ClinicalTrials.gov
PubMed
Central
Privacy Policy
|
 |
-
Reversible intermittent rhythmic
myoclonus with fluoxetine in presumed Pick's
disease.
Lauterbach EC.
Department of
Psychiatry and Behavioral Sciences, Mercer University School of
Medicine, Macon, Georgia 31207.
A 61-year-old man with presumed
Pick's disease was successfully treated with fluoxetine for pathological
affect. Severe intermittent, rhythmically repetitive trains of myoclonus
developed suddenly the following year. A dystonic-like component
involving the shoulder region and a decrescendo frequency pattern were
observed. Myoclonus involved the face, palate, shoulder, neck, upper
chest and back, diaphragm, hips, and upper extremities, especially on
the right side. Movements were not influenced by postural adjustments,
startle, or other stimuli. Movements proved insensitive to benztropine
but abated with discontinuation of fluoxetine. Rechallenge with
fluoxetine or trazodone evoked the movements, whereas clonazepam and
chloral hydrate abolished the movements. The pattern of myoclonus is
unlike previous reported cases and may relate to activation of serotonin
5HT1A receptors (possibly supersensitive in Pick's disease) or to
hypodopaminergia. Although fluoxetine may be useful as adjunct therapy
in dementing disorders, caution may be warranted in its use in Pick's
disease.
Publication Types:
PMID: 8041377 [PubMed - indexed for
MEDLINE]
|