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1: Tidsskr Nor Laegeforen. 2001 Jan 20;121(2):177-8.

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[Selective serotonin uptake inhibitors and pancreatitis]

[Article in Norwegian]

Kvande KT, Madsen S.

Medisinsk avdeling Statens legemiddelverk Sven Oftedalsvei 6 0950 Oslo. kristin.kvande@slk.no

BACKGROUND: About 2% of all cases of pancreatitis are drug-induced. Several drugs cause pancreatitis, including selective serotonin reuptake inhibitors (SSRIs). MATERIAL AND METHODS: Two Norwegian adverse drug event reports and a review of the international WHO adverse drug reactions database form the basis for this discussion. We found a total of 160 cases of pancreatitis associated with SSRIs. RESULTS: Our findings support the notion that SSRIs may trigger pancreatitis in rare cases. The course of the disease may be severe and even fatal. INTERPRETATION: Physicians should be aware of the possibility that SSRIs may trigger pancreatitis. Patients taking SSRIs should be evaluated for pancreatitis if they report abdominal pain of unknown cause.

Publication Types:

• Case Reports

PMID: 11475194 [PubMed - indexed for MEDLINE]

Jan 29 2004 15:06:34