Periodicals Home

Search

User Pref

Help

J Peds Home

Table of Contents

All Issues

Order

About this Journal

<< Issue

>> Issue

Full-Text Version

OMIM Links

GenRx Links

PubMed Citation

Related Articles

<< Abstract

>> Abstract

LSD flashback syndrome exacerbated by selective serotonin reuptake inhibitor antidepressants in adolescents

Howard Markel, MD, PhD [MEDLINE LOOKUP]
Andrew Lee, MD [MEDLINE LOOKUP]
Ronald D. Holmes, MD [MEDLINE LOOKUP]
Edward F. Domino, MD [MEDLINE LOOKUP]

Two adolescents with a long history of abuse of lysergic acid diethylamide (LSD) and symptoms consistent with major depressive disorder, on initiation of antidepressant therapy with selective serotonin reuptake inhibitor agents, had the new onset or worsening of LSD flashback syndrome. The similarity in neuroreceptor physiology for both LSD and serotonin suggests that the LSD flashback syndrome may be induced by these drugs in patients with a history of LSD abuse. (J PEDIATR 1994;125:817-9)

LSD Lysergic acid diethylamide SSRI Selective serotonin reuptake inhibitor 5-HT 5-Hydroxytryptamine

Publishing and Reprint Information

TOP

• From the Departments of Pediatrics and Communicable Diseases, and Pharmacology, University of Michigan Medical School, Ann Arbor
• Supported in part by a National Research Service Award (Dr. Markel), National Institutes of Health, National Center for Human Genome Research (grant No. 5 F32 HG00037-02).
• Submitted for publication Oct. 19, 1994;
  
• Accepted June 7, 1994.
  
• Reprint requests: Howard Markel, MD, PhD, Assistant Professor of Pediatrics and Communicable Diseases, University of Michigan Medical School, 1924 Taubman Center, Box 0318, Ann Arbor, MI 48109.
  

• Copyright © 1994 by Mosby-Year Book, Inc.
  

• 0022-3476/94/$3.00 + 0 9/26/58251