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Citalopram-induced generalized
lipidosis in rats.
Lullmann-Rauch R, Nassberger
L.
This study was focussed on the question of whether or not
the potential antidepressant citalopram, which is an amphiphilic
cationic compound, can induce generalized lipidosis in animals. In a
short term experiment, female rats were treated with a single oral dose
(100 mg/kg) and the lymph node was examined by electron microscopy; a
significant number of lymphocytes showed lamellated inclusions
indicating lipidosis. In a subchronic experiment (7 weeks) female rats
received 140 mg/kg per day, and several organs were examined. Marked
lipidosis-like alterations were found in lymph node, adrenal cortex and
medulla, kidney, lung and in a sympathetic ganglion. Mild lysosomal
alterations were found in hepatocytes and retinal pigment epithelium.
Lipidosis was very weak, or absent, in retinal ganglion cells,
trigeminal ganglion cells and in hypothalamic neurosecretory perikarya.
In addition, citalopram produced myopathic alterations in soleus muscle
resembling those previously induced with other cationic amphiphilic
drugs. Myopathy persisted during a drug-free recovery period of 4 weeks,
whereas generalized lipidosis was reversible within 2-4 weeks. The
present results support a previously proposed concept concerning the
structure-response relationships underlying drug-induced
lipidosis.
PMID: 6303044 [PubMed - indexed for MEDLINE]
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