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[SIADH with epileptic seizures and
coma in fluoxetine therapy]
[Article in
German]
Romerio SC, Radanowicz V, Schlienger
RG.
Medizinische Universitatsklinik, Kantonsspital
Liestal.
Hyponatremia and the syndrome of inappropriate
antidiuretic hormone secretion (SIADH) have been associated with several
psychotropic drugs e.g., carbamazepine, neuroleptics, tricyclic
antidepressants and more recently selective serotonin reuptake
inhibiting (SSRI) antidepressants. SSRIs have gained widespread use in
elderly depressed patients because of their favourable adverse effect
profile. However, SSRIs have recently been associated increasingly with
SIADH. We describe a 82-year old patient who was hospitalised after
witnessed convulsions ten days after initiation of fluoxetine therapy
for depression. She had hyponatremia and increased urine osmolarity
suggesting SIADH. Using this case we discuss the clinical symptoms,
aetiology, differential diagnosis and therapy of drug-induced
SIADH.
Publication Types:
PMID: 10731855 [PubMed - indexed for
MEDLINE]
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