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Mirtazapine-induced
hepatotoxicity.
Hui CK, Yuen MF, Wong WM, Lam SK,
Lai CL.
Department of Medicine, The University of Hong Kong,
Queen Mary Hospital, Hong Kong, China.
We report two cases of
hepatotoxicity induced by mirtazapine. Two women treated for depression
with mirtazapine developed severe hepatotoxicity because of the drug. In
the first case, mirtazapine was prescribed for 3 years and the patient
developed derangement in liver function with prolonged jaundice, which
improved after the withdrawal of mirtazapine. The use of mirtazapine in
the second case was associated with prolonged jaundice, which only
recovered 3 months after the withdrawal of mirtazapine. The cause of
mirtazapine-induced liver toxicity was unknown, and to our knowledge,
these are the first reported cases of mirtazapine-induced prolonged
jaundice.
Publication Types:
PMID: 12192206 [PubMed - indexed for
MEDLINE]
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