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[High-dose fluoxetine-induced
mania. Review and case report]
[Article in
Spanish]
Ruiz M, Vairo C, Matusevich D, Finkelsztein
C.
Servicio de Psiquiatria del Hospital Italiano de Buenos
Aires, Argentina. mruiz@elaleph.com
We report the case of a 53
year old woman who attempted suicide taking one high-dose of fluoxetine,
developing a manic episode 19 days later. We also make a review about
antidepressant-induced mania. In patients with mood disorder, the
frequency of antidepressant-induced mania switch has been estimated to
be 3.7 to 33%, varying across studies that included different diagnoses
and different antidepressant treatments. Among the used data basis
(Medline) there are papers reporting fluoxetine-induced mania. All of
them include patients receiving adequate dose and time fluoxetine
treatment. We found no reports of switch occurring after one high-dose
of fluoxetine. As the impact on the clinical management of
antidepressant-induced manic switches is quite high, several studies
have focused on the possible clinical predictors of this phenomenon. By
the time, is not possible to determine whether a manic episode is due to
the natural course of bipolar disorder or to the medication. Thus, the
phenomenon of antidepressant-induced mania should be defined and
investigated with controlled prospective studies.
Publication
Types:
- Case Reports
- Review
- Review, Tutorial
PMID: 12192418 [PubMed - indexed for
MEDLINE]
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