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Venlafaxine-associated vaginal
bleeding.
Linnebur SA, Saseen JJ, Pace
WD.
Department of Pharmacy Practice, School of Pharmacy,
University of Colorado Health Sciences Center, Denver 80262, USA.
sunny.linnebur@uchsc.edu
A 41-year-old amenorrheic woman started
taking venlafaxine 37.5 mg/day for treatment of depression; 7 days
later, she experienced vaginal bleeding, which ceased 1 day after she
stopped taking the drug. On rechallenge with venlafaxine, she again
experienced vaginal bleeding that resolved after discontinuation. We
found no published reports describing vaginal bleeding associated with
venlafaxine. However, premarketing and postmarketing data report similar
adverse effects in patients taking the agent. In addition, several cases
of menstrual irregularities have occurred with two other
antidepressants: fluoxetine and bupropion. This case report supports
previous surveillance data indicating that venlafaxine may cause vaginal
bleeding.
Publication Types:
PMID: 12013367 [PubMed - indexed for
MEDLINE]
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