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Serotonin and suicidality: the
impact of fluoxetine administration. II: Acute neurobiological
effects.
Anderson GM, Segman RH, King
RA.
Yale Child Study Center, Yale University School of
Medicine, New Haven, CT, USA.
Despite the demonstrated
anti-depressant efficacy of the selective serotonin reuptake inhibitors
(SSRIs), increased suicidal ideation and/or agitation have been reported
in a small proportion of individuals receiving fluoxetine or other
SSRIs. Part II of this review examines fluoxetine's acute effects on
serotonergic functioning. Although acute fluoxetine administration
produces a short-term compensatory decrease in the firing of 5-HT
neurons, the neurobiological data reviewed suggests that this decrease
probably does not lead to an over-compensatory net decrease in 5-HT
functioning. The implications of fluoxetine's complex effects on the
5-HT systems are discussed with respect to clinical practices and future
research.
Publication Types:
PMID: 7622346 [PubMed - indexed for
MEDLINE]
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