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[Severe hyponatremia during
treatment with fluoxetine]
Miranda M, Armijo G, Miranda P.
Neurologia, Hospital Felix Bulnes, Chile.
inhibitors, used as antidepressants, may cause hyponatremia due to a
syndrome of inappropriate antidiuretic hormone, specially in elders.
Thirty cases with such complication have been reported in the last six
years. We report a 76 years old female with a hypertensive cardiopathy
and paroxysmal atrial fibrillation treated with amlodipine and sotalol.
Five days after starting fluoxetine, the patient presented with a
confusional state, gait instability and tremor. Laboratory assessment
disclosed a plasma sodium of 115 meq/L. Fluoxetine was discontinued and
fluids were restricted. The clinical condition of the patient improved
and hyponatremia abated. Hyponatremia must be born in mind as a
potential side effect of serotonin reuptake
PMID: 10436720 [PubMed - indexed for