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Selective serotonin reuptake
inhibitor usage patterns as risk factors for
hospitalization.
Sheffield RE, Lo Sasso AT, Young
CH, Way K.
PCS Health Systems, Scottsdale, AZ,
USA.
The authors examined how differences in SSRI utilization
affect the risk of hospitalization among persons with depression. In
particular, they decompose how different types of drug therapy affect
hospitalization and how that effect varies with the usage pattern of the
drug. Using retrospective medical and pharmacy claims from a Midwestern
health maintenance organization, they employed multiple logistic
regression analyses of patients newly treated for depression. Their
findings were that (a) paroxetine may be a significant risk factor for
early discontinuation compared with fluoxetine; and (b) sertraline
initiation among stable-use patients may lower the risk of
hospitalization. However, initiation on paroxetine or sertraline rather
than fluoxetine may increase the risk of hospitalization among patients
not exhibiting a stable usage pattern.
PMID: 12680617 [PubMed -
indexed for MEDLINE]
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