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Suicide attempt by pure citalopram
overdose causing long-lasting severe sinus bradycardia, hypotension and
syncopes: successful therapy with a temporary
Rothenhausler HB, Hoberl C, Ehrentrout
S, Kapfhammer HP, Weber MM.
Department of Psychiatry,
Ludwig-Maximilians-University of Munich, Germany.
In few cases, pure citalopram
overdose at doses above 600 mg showed electro-cardiographic changes with
prolonged QT intervals and sinus bradycardia gradually resolving within
12-24 hours after intoxication. We report on a 32-year-old patient with
borderline personality disorder (BPD) who ingested a total of 800 mg
citalopram to attempt suicide due to an interpersonal disappointment.
She developed severe sinus bradycardia with a minimal pulse rate of
41/min within about 4 hours after intoxication lasting up to six days
during intensive care unit (ICU) treatment. Further, hypotension and
syncopes occurred. No QT interval prolongations were recorded. To our
knowledge, this is the first case report of pure citalopram
overdose-induced long-lasting sinus bradycardia associated with severe
hypotension and intermittent syncopes that required therapy with a
PMID: 10958266 [PubMed - indexed for