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Paroxetine and
galactorrhea.
Bonin B, Vandel P, Sechter D,
Bizouard P.
Service de Psychiatrie et Psychologie Medicale,
Centre Hospitalo-Universitaire, Besancon, France.
The authors
report a case of galactorrhea following antidepressant treatment where
paroxetine might be responsible. Paroxetine is a selective serotonergic
reuptake inhibitor (SSRI). Galactorrhea occasionally is a
dopamine-mediated side effect observed with neuroleptic drugs. However,
the ability to produce extrapyramidal side effects is known for
tricyclic as well as for SSRIs. Thus the potential of SSRIs to induce
dopamine-dependent side effects is a clinical reality and it was not
surprising to observe galactorrhea due to paroxetine. However, in a
review of the literature no reported cases of galactorrhea associated
with paroxetine were found.
Publication Types:
PMID: 9271780 [PubMed - indexed for
MEDLINE]
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