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Fluoxetine: adverse effects and
drug-drug interactions.
Messiha
FS.
University of North Dakota School of Medicine, Grand
Forks.
This overview summarizes the major and minor side effects
and drug interactions of fluoxetine. The adverse reactions include the
"serotonin syndrome", cardiovascular complications, extrapyramidal side
effects such as akathisia, dyskinesias, and parkinsonian-like syndromes
and an apparently increased risk of suicidality. Fluoxetine-induced
mania and hypomania, seizures and sexual disorders are evaluated along
with minor symptoms of allergic reactions, stuttering, hematological
changes, psoriasis, and inappropriate secretion of the antidiuretic
hormone. The major fluoxetine-drug interactions involve the amino acids
L-dopa and L-tryptophan, anorexiants, anticonvulsants, antidepressants,
anxiolytics, calcium channel blockers, cyproheptadine, lithium salts,
and drugs of abuse. The underlying mechanism and the paradoxical effects
of fluoxetine are addressed.
Publication Types:
PMID: 8254702 [PubMed - indexed for
MEDLINE]
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