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learning in the Morris water maze induced by serotonin reuptake
inhibitors in rats.
Majlessi N, Naghdi
Department of Physiology and Pharmacology, Pasteur
Institute of Iran, Pasteur Ave., Tehran 13164, Iran.
The effects of selective serotonin
reuptake inhibitors citalopram and fluoxetine on spatial learning were
assessed in rats. Adult male rats were subjected to 4 days of training
in the Morris water maze with the invisible platform. Animals received
different doses of citalopram (1-8 mg/kg; i.p.) or fluoxetine (1-16
mg/kg; i.p.) or their vehicles (saline or distilled water respectively)
30 minutes before training each day. The results showed that citalopram
at doses of 4 and 8 mg/kg and fluoxetine at doses of 8 and 16 mg/kg
significantly increased latencies to find the platform and traveled
distances compared to the control group. Therefore, it appears that
selective serotonin reuptake inhibitors can cause learning deficits in
complex spatial tasks such as Morris water maze. Copyright 2002
Lippincott Williams & Wilkins.
PMID: 12122314 [PubMed -
indexed for MEDLINE]