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Selective serotonin reuptake
inhibitor-induced rash: case report and review of the
literature.
Sannicandro TJ, Farrar MC, Markowitz
JS.
Institute of Psychiatry, Medical University of South
Carolina, Charleston 29425, USA.
Selective serotonin reuptake
inhibitors (SSRIs) are one of the most frequently prescribed classes of
drugs. Rashes induced by SSRIs seldom have been reported in the
literature. Computerized MEDLINE and Current Contents searches yielded a
report of two cases of rash induced specifically by paroxetine. We
describe a patient who developed a rash that appeared on day 3 of
treatment with oral paroxetine 20 mg/day. Her rash was morbilliform,
pruritic, and generalized over the trunk and limbs, with some facial
involvement. There was no palm or sole involvement. The patient reported
that she had experienced a similar reaction to fluoxetine, which may
suggest a drug class effect. The rash resolved within 2 days of drug
discontinuation and treatment with oral diphenhydramine and topical
hydrocortisone cream.
Publication Types:
- Case Reports
- Review
- Review of Reported Cases
PMID: 11939687 [PubMed -
indexed for MEDLINE]
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