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1: Ann Clin Psychiatry. 2000 Sep;12(3):167-70. Related Articles, Links

Melancholic symptoms during concurrent olanzapine and fluoxetine.

Nelson LA, Swartz CM.

St. Louis University School of Medicine, Department of Psychiatry, Missouri 63104, USA. lnelson@stlcop.edu

The concomitant use of olanzapine and fluoxetine has been advocated for the treatment of various psychiatric disease states. We describe a case in which the combination of olanzapine and fluoxetine appears to have caused the psychopathology of melancholic depression requiring hospitalization in a 40-year-old female. Postulated mechanisms for this drug interaction, particularly CYP450 isoenzyme inhibition by fluoxetine, is discussed.

Publication Types:
  • Case Reports

PMID: 10984007 [PubMed - indexed for MEDLINE]


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