Psychoactive substances, Serotonin and the Pineal Gland
Melatonin is not the only neurotransmitter made out of serotonin.
Other serotonin derivatives which are psychoactive or mind altering are thought to be
produced by the Pineal Gland.
The necessary enzymes for the formation of these molecules exist in high concentrations
in the Pineal Gland.
By acute administration -either smoked or injected into the bloodstream- of one of these
serotonin derivatives, also known as tryptamines,
humans will experience an altered state of consciousness, which can differ from "hypnogogic
dream-like states" to full blown "hallucinatory psychosis."
It is recently thought that these molecules are responsible for our dream imagery. They are, just
like melatonin, released at night, prior to REM-sleep and interact within
the central nervous system.
are such tryptamines and serotonin derivatives.
They can produce colour imagery, out of body(like) experiences, lucid dreams, visions of
beings and/or animals, mystical states, subjective "other realities" as well as experiences
of "being somewhere else."
DMT and 5-MeO-DMT can be extremely frightening when smoked or injected for the first time.
Another psychoactive serotonin derivative produced by the Pineal Gland
is called Pinoline, also
known as 6-Methoxy-Tetra-Hydro-Beta-Carboline (6-Methoxy-THBC).
Pinoline is not a tryptamine but a beta-carboline. It is similar to harmaline,
an extract from the psychoactive plants Banisteriopsi Caapi and Psycotria Viridis
in the Amazonian Rain Forest. Harmaline is the active ingredient in a psychedelic cocktail called
It is used by Indian tribes and shamans to communicate with the spirits telepathically while
they "dream awake."
Also a very interesting molecule is Bufotenine, also known as
5-Hydroxy-Dimethyl-Tryptamine (5-HDT). Although bufotenine is both a serotonin derivative and a
tryptamine it is not established yet if it is produced by the Pineal Gland.
It also occurs naturally in humans but in very small amounts. In higher amounts it
becomes highly toxic. Bufotenine also derives from the dermal substance of a toad.
The Shamans of the ancient Maya ingested bufotenine on special ceremonies. It would turn
the user into a "mouthpiece for the gods." The effects seem as being possessed by an evil
3.b. The Disrupted Serotonin Cycle & The Malfunctioning Pineal Gland
SSRI-AntiDepressants inhibit the re-uptake of serotonin into the firing synapse
of the serotonergic neuron. As a result, more serotonin is fired continuously to the
receiving dendrite which results in more serotonin in the synaptic cleft. Because of this
continuous action, the natural cycle of serotonergic activity during daytime and serotonergic inactivity at
night gets disrupted! Under the influence of the SSRI-AntiDepressant, the serotonergic
system now works overtime, 24 hours a day. The implications of a disrupted serotonin
cycle could be as follows:
What can happen, when the serotonergic system isn't cycling anymore, in a natural
circadian rhythm, is that daily consciousness will shift closer and closer to the
"dream state". The verge between reality and dreaming will gradually become blurred.
The lack of rhythm is the cause. Under the influence of an SSRI-AntiDepressant, serotonin
levels won't fluctuate anymore, but remain continuously high.
Many SSRI-AntiDepressant users reported that they had problems to distinguish reality from
dreaming when they woke up from a dream and that it took quiet some time to realize that
they had been dreaming instead of experiencing something real.
Consciousness on the verge of Dreaming and Reality
We already know that an active serotonergic system suppresses REM sleep and thereby REM
related dreaming. Our brains need to dream. Although we do not always remember our dreams,
we are dreaming around 4 to 5 times every night. Only a few days of sleep deprivation
(and thus dreaming) will cause the brain to hallucinate.
To counteract the SSRI-AntiDepressant induced suppression of REM related dreaming,
the brain litterly forces it's dreams upon us. This doesn't necessarily has to be a rebound
of REM related dreaming triggered by the brainstem mechanisms (since an active serotonergic
system suppresses these mechanisms), but could as well be induced by epileptic activity
in the forebrain, triggering forebrain dreams or nightmares, as previously discussed.
Most critical, when the normal brainstem REM mechanisms are not included in these
forebrain dreams or nightmares, then they won't turn on the cells in the medulla that
inhibit all motor activity. The implications of this contradictional dream sleep could be
Next to experiencing hallucinations, suppression of REM sleep can lead to an other serious disorder.
On page 45 of her brilliant book "Prozac: Panacea or Pandora?", Doctor Ann Blake Tracy
introduced us to the violent REM Sleep Behaviour Disorder, caused by psychoactive drugs such
as SSRI-AntiDepressants. This condition means a sleepwalk nightmare wherein the patient acts
out violent dreams while sleepwalking. The violent REM Sleep Behaviour Disorder is
further discussed in chapter 7: "Sleep disorders, serotonin and the SSRI's" on page 182.
From SSRI-AntiDepressant induced "consciousness on the verge of dreaming and reality", it
will be a very close step to SSRI-AntiDepressant induced "psychosis" or "hallucinatory
psychosis", in which extremely lifelike dreams/nightmares become hallucinations and will
be experienced for real!
Many (former) SSRI-AntiDepressant users reported major perception changes, altered states
of consciousness, a disturbed sense of reality and out of character behaviour.
The symptoms vary from urges to spend money excessively, flamboyant/provocative behaviour,
indifference and mania, till abnormal dream and thought patterns, racing thoughts, hearing
voices or telepathic like thoughts and akathisia (an extreme mental state of inner restlessness).
Also frequently reported is the feeling of living in a bubble, feeling possessed or living
in a dream.
I questioned myself if it could be possible that the psychoactive serotonin derivatives,
which are thought to be secreted by the Pineal Gland,
could play a (secondary) role in these reported altered states of consciousness and behaviour.
Under the influence of an SSRI-AntiDepressant, serotonin levels in the Pineal Gland could
increase to excessive, possibly even toxic amounts.
Although I had to revise my previous hypothesis regarding increased melatonin levels in the
eyes (melatonin levels didn't increase under the influence of an SSRI-AntiDepressant), this
time I found more support for the hypothesis that certain serotonin derivatives, like the
psychoactive tryptamines DMT, 5-MeO-DMT and Bufotenine, could very well increase on account
of an SSRI-AntiDepressant.
In an article published on the internet, Dr. Callaway states that the natural re-uptake of
serotonin account for most of the inactivation of these psychoactive tryptamines.
Blocking the re-uptake of serotonin, like SSRI-AntiDepressants do, could not only increase
serotonin levels but also the levels of the other psychoactive tryptamines, whether or not
secreted by the Pineal Gland.
Furthermore, Dr. Callaway discusses the possible correlation between tryptamines and our
"Since these same Psychoactive tryptamines occur in humans, it is possible that their
activity may be promoted by the actions of endogenous beta-carbolines for normal
psychological processes; e.g. the production of visual / emotive imagery in sleep.
The periodic altering of consciousness in sleep may even be necessary for the maintenance
of normal mental health, since only a few days of sleep deprivation will result in a
seepage of hallucinatory phenomena into the waking state."
-Tryptamines, Beta-carbolines and You. Dr J.C. Callaway, Dept. of Pharmaceutical
Chemistry, University of Kuopio, Finland
An absolutely shocking discovery was the correlation between high serotonin levels in
the Pineal Gland and certain mental disorders!
During autopsy on recently dead mental patients,
Giarmin and Freedman (see chapter 3.a.) discovered that the Pineal Glands of those who had
suffered from specified mental disorders, showed a
considerable excess of serotonin in their Pineal Glands. The average amount of serotonin
found in the Pineal Glands of normal persons is about 3.14 to 3.52 micrograms per gram of
One schizophrenic was found to have a Pineal Gland containing 10 micrograms of serotonin,
around 3 times higher, while another patient, a sufferer from delirium tremens, had a
Pineal Gland containing 22.82 micrograms of serotonin, around 10 times higher then the average amount!
This is a most interesting research contemplating the similarities between symptoms of
schizophrenia or schizophrenic psychosis and SSRI-AntiDepressant induced perception changes,
altered states of consciousness, disturbed sense of reality and out of character behaviour in
As a direct result from the actions of the SSRI-AntiDepressant (disruption of the natural
serotonin cycle), serotonin levels in the Pineal Gland could gradually increase to excessive
amounts comparable to the excessive amounts of serotonin in the Pineal Glands of recently dead
mental patients. Hence, the production of psychoactive serotonin derivatives increases, which
can lead to excessive amounts of these molecules in the brain.
The combined effects of suppression of REM sleep, excessive amounts of serotonin in the
Pineal Gland, as well as elevated levels of psychoactive serotonin derivatives, could make
an individual experience hypnogogic dream-like states (which depersonalise an individual
from their own emotions) to full blown "hallucinatory psychosis."
Tardive Dyskinesia & Parkinsonism
Other frequently reported neurological side-effects from SSRI-AntiDepressants, involving
loss of motor control, are called Tardive Dyskinesia/Dystonia
Tardive Dyskinesia/Dystonia is the collective noun for various abnormal involuntary body
movements like: tics and twitches in the face or/and around the eye, muscle spasms, muscle
contractions in the neck, jaw, tongue, or/and
shoulders and irregular jerking movements in body parts.
Parkinsonism is a term used to indicate
symptoms similar to those seen in Parkinson's disease like: apathy or indifference,
tremors and muscle stiffness.
Dr. Joseph Glenmullen (Prozac Backlash) introduced us to these terms and defined them
as related to damaged dopaminergic neurons in the limbic system.
The SSRI-AntiDepressant induced
increased serotonin would cause a down regulation of the neurotransmitter dopamine and therefore
cause the same damage at dopaminergic neurons as observed with neuroleptic (anti-psychotic)
However, in 4 PubMed articles
Tardive Dyskinesia and Parkinsonism are associated with
disturbances of serotonin and melatonin secretion and a malfunctioning Pineal Gland.
The represented cases involve neuroleptic-induced movement disorders related to
Pineal Gland calcification. There were "significant differences between the severity of
dystonic movements in patients with no Pineal Gland calcification and those with pathologically
enlarged Pineal Gland calcification."
Could there be a similar existing pattern in (former) SSRI-AntiDepressant users?
Further research will be needed to establish if (former) SSRI-AntiDepressant users who
have more or less severe Tardive Dyskinesia/Dystonia and Parkinsonism, are
actually suffering from a malfunctioning Pineal Gland, whether or not calcified.
This research could involve measurements of plasma melatonin levels.
The Endocrine System
A malfunctioning Pineal Gland and disturbances in serotonin and melatonin secretion could
also lead to excessively secreted hormones of the Endocrine System.
Women who are experiencing side-effects after discontinuing their SSRI-AntiDepressant,
mentioned a worsening of their problems around their ovulation period.
Normally, the Pineal Gland releases melatonin to sedate the Endocrine Organs/Glands when
they are too active or stressed. When this doesn't happen, because of the disturbed natural
melatonin cycle, then the hormones of the Endocrine System which usually are released
every period, could now cause problems.