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An acute ischaemic event
associated with the use of venlafaxine: a case report and proposed
pathophysiological mechanisms.
Reznik I, Rosen Y,
Rosen B.
Abarbanel Mental Health Centre, Rabin Medical
Centre-Beilinson Campus, Petah-Tikva, Israel.
ilyarez@netvision.net.il
Venlafaxine, a structurally novel
antidepressant, belongs to a new generation of antidepressants--the
serotonin/noradrenaline reuptake inhibitors. In clinical trials,
venlafaxine was found safe and effective in most patients. However,
significant changes in vital signs (hyper- and hypotension) and cardiac
conduction abnormalities were observed in a few patients, notably in
elderly patients. We present a case of an elderly woman with a
pre-existing history of ischaemic heart disease, who was treated with
venlafaxine, and developed acute myocardial ischaemia within the first
week of treatment. This is the first report of a possible association
between an acute cardiovascular event and venlafaxine. The association
of venlafaxine treatment with ischaemic events could be explained by its
unique pharmacological and haemodynamic properties.
Publication
Types:
PMID: 10475726 [PubMed - indexed for
MEDLINE]
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