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[Paroxetine-induced
neuroleptic malignant syndrome]
[Article in
German]
Heinemann F, Assion HJ, Hermes G, Ehrlich
M.
Neurologische Abteilung, St.-Josef-Krankenhaus,
Moers.
We report on a 22-year-old schizophrenic patient who
attempted suicide and suffered an epidural hemorrhage. 16 days after the
neurosurgical operation. After several weeks of treatment with
promethazine, 1 day after intake of paroxetin he partially lost
consciousness and developed extrapyramidal symptoms and vegetative
disorders. Hyper-Ck-aemia up to 680 U/l was observed. Malignant
neuroleptic syndrome (MNS) was diagnosed, which led to withdrawal of
paroxetin and promethazine. He was put on dantamacrine and amantadine
until the symptoms resolved. To date there have been few reports on MNS
under tricyclic antidepressants and selective serotonin inhibitors. The
influence of the central serotonergic system on the pathophysiology of
MNS is discussed.
Publication Types:
PMID: 9380213 [PubMed - indexed for
MEDLINE]
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