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A depressed
myocardium.
Partridge SJ, MacIver DH, Solanki
T.
Taunton and Somerset NHS Trust, England, United Kingdom.
samuel@langford134.freeserve.co.uk
BACKGROUND: Venlafaxine is a
potent neuronal serotonin and noradrenaline re-uptake inhibitor, and to
a lesser extent an inhibitor of dopamine reuptake. Paroxetine is a
potent selective inhibitor of serotonin reuptake. CASE REPORT: A
27-year-old man ingested 1987.5 mg of venlafaxine and 360 mg of
paroxetine. He subsequently developed systolic and diastolic
hypertension, transient electrocardiographic abnormalities, and an area
of persistent myocardial damage. He recovered from his overdose with his
blood pressure and electrocardiogram returning to normal. The area of
myocardial damage was documented on echocardiogram as an area of marked
hypokinesia at the basal anterior septum. Despite the absence of
confirming blood levels or the absolute exclusion of cocaine, this case
indicates that venlafaxine and paroxetine have the potential for serious
cardiotoxicity when taken in overdose.
Publication Types:
PMID: 10930064 [PubMed - indexed for
MEDLINE]
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