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Enhancement of stress-induced
pituitary hormone release and cardiovascular activation by
antidepressant treatment in healthy men.
Laboratory of Pharmacological Neuroendocrinology,
Institute of Experimental Endocrinology, Slovak Academy of Sciences,
A randomized, double-blind,
placebo-controlled trial was performed to verify the suggestion that (i)
in accordance with the results of animal studies, treatment with
antidepressants inhibits hormone release in response to stressful
stimulation in humans and (ii) drugs with opposing effects on brain
serotonine (citalopram and tianeptine) exert similar modulatory effects
on neuroendocrine activation during stress. Healthy male volunteers were
treated with citalopram (20 mg), tianeptine (37.5 mg) or placebo for 7
days. As a stress stimulus, insulin-induced hypoglycaemia was used.
Measurement of hormone concentrations revealed an enhanced release of
adrenocorticotropic hormone and growth hormone in response to stress of
hypoglycaemia in subjects treated with both antidepressants used. A
similar augmentation was observed in systolic blood pressure.
Stress-induced prolactin release was potenciated by citalopram only.
Plasma renin activity, epinephrine, norepinephrine and cortisol levels
failed to be modified by antidepressants. The present study demonstrates
that (i) repeated antidepressant treatment in healthy men does not
inhibit, but enhances, neuroendocrine activation during stress and (ii)
such effects were observed after treatment with antidepressants having
opposing actions on brain serotonin, indicating involvement of
- Clinical Trial
- Randomized Controlled Trial
PMID: 12236631 [PubMed -
indexed for MEDLINE]