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Volume
125, Issue
5, Pages 817-819 (November 1994)

27 of 56

LSD flashback syndrome
exacerbated by selective serotonin reuptake inhibitor
antidepressants in adolescents

ABSTRACT

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Howard
Markel a,
Andrew
Lee a,
Ronald
D. Holmes a
and Edward
F. Domino a

Received 19 October 1994;accepted 7
June 1994.

Abstract
Two adolescents with
a long history of abuse of lysergic acid diethylamide (LSD)
and symptoms consistent with major depressive disorder, on
initiation of antidepressant therapy with selective serotonin
reuptake inhibitor agents, had the new onset or worsening of
LSD flashback syndrome. The similarity in neuroreceptor
physiology for both LSD and serotonin suggests that the LSD
flashback syndrome may be induced by these drugs in patients
with a history of LSD abuse. ( 1994;125:817-9)

© 1994 Mosby, Inc.. All rights
reserved.

27 of 56

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