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From: Subject: DenverPost.com - NATION/WORLD Date: Mon, 13 Sep 2004 20:18:25 +0200 MIME-Version: 1.0 Content-Type: multipart/related; boundary="----=_NextPart_000_0000_01C499CE.D342CE60"; type="text/html" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2800.1441 This is a multi-part message in MIME format. ------=_NextPart_000_0000_01C499CE.D342CE60 Content-Type: text/html; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.denverpost.com/Stories/0,1413,36~11676~2394188,00.html DenverPost.com - = NATION/WORLD

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Article Published: Sunday, = September=20 12, 2004

Drug=20 taken by Columbine killer linked to increased mania

By = Anne C.=20 Mulkern
Denver Post Staff Writer

Washington - Children and teenagers taking the=20 antidepressant Luvox - the drug taken by Columbine shooter = Eric=20 Harris - experienced mania at four times the rate of adults, = a study=20 submitted to drug regulators shows.=20

There is no way to know for sure how much the drug = influenced=20 Harris psychologically or chemically. His medical records = are under=20 court seal, and attorneys in the case are forbidden to = discuss what=20 they know. The coroner has said Harris had Luvox in his = system when=20 he died.

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But new information coming out about the class of = antidepressants=20 that includes Luvox renews the questions about Harris and = the drug.=20 The U.S. Food and Drug Administration in March issued a = warning that=20 people taking antidepressants have become violent and = suicidal,=20 though the FDA said it had not established a direct = connection=20 between the drug and the events. Canadian health authorities = in June=20 forced makers of Luvox and eight similar antidepressants to = add a=20 warning that there have been violent acts associated with = the=20 drugs.

"It does become much more important and legitimate to = ask" about=20 Columbine, said Harvard psychiatrist Joseph Glenmullen, who = has=20 written about antidepressant-triggered violence.

A lawsuit filed against the maker of Luvox, Solvay=20 Pharmaceuticals, was dropped in 2003 after the company made = a=20 $10,000 donation to charity.

"We believe that the product had absolutely nothing to do = with=20 Mr. Harris' actions," Solvay spokeswoman Gabrielle Braswell = said in=20 an interview. "You have to bear in mind that he was acting = with=20 Dylan Klebold, who was not taking Luvox to my knowledge or = any other=20 antidepressant at the time."

Dr. Peter R. Breggin, the psychiatrist who planned to = testify in=20 the lawsuit, said he's positive Harris was suffering from=20 Luvox-induced mania. Another psychiatrist said it amounted = to the=20 "Twinkie defense" to blame violence on antidepressants.

The year-long planning of the attack weighs against the=20 possibility that the antidepressant influenced Harris, most = said,=20 though Glenmullen and others said it could have made him = less=20 empathetic to others' pain. Glenmullen believes all of the = new=20 antidepressants can trigger suicide in the first few weeks = they're=20 taken, but that there can also be reactions after months or=20 more.

Luvox has not been actively marketed in the U.S. since = 2002 but=20 is prescribed in its generic form, doctors said. It was = approved by=20 the FDA for use in pediatric obsessive-compulsive disorder = in 1997.=20 It had already been approved for adults.

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All contents Copyright 2004 The Denver = Post or=20 other copyright holders. All rights reserved. This material may = not be=20 published, broadcast, rewritten or redistributed for any = commercial=20 purpose.

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9/13/2004

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